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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2003 Volume 23 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells

  • Authors:
    • Tadashi Igishi
    • Masaaki Mikami
    • Kaori Murakami
    • Shingo Matsumoto
    • Yasushi Shigeoka
    • Hirofumi Nakanishi
    • Kazuhito Yasuda
    • J. Silvio Gutkind
    • Yutaka Hitsuda
    • Eiji Shimizu

  • View Affiliations / Copyright

    Affiliations: Third Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. igishi@grape.med.tottori-u.ac.jp
  • Pages: 1079-1085
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijo.23.4.1079
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Abstract

Intracellular signaling through Rho-associated coiled-coil forming kinase (ROCK) is a target of antimetastatic therapy and is proposed to be involved in carcinogenesis. Focal adhesion kinase (FAK) functions downstream of ROCK and participates in anti-apoptotic signaling. We hypothesized that a specific ROCK inhibitor, Y-27632, may exert a pro-apoptotic effect in combination with anticancer agents through the suppression of FAK. A549 lung carcinoma cells were treated with Y-27632 and cisplatin. The simultaneous combination did not exert any additional effect, whereas sequential treatment, in which cisplatin followed Y-27632, enhanced cytotoxicity in concentration- and time-dependent manner. Y-27632 did not suppress tyrosine phosphorylation of FAK in A549-FAK, the active form of FAK expressing A549 cells, as observed in parental cells. Nevertheless, the pretreatment of A549-FAK cells with Y-27632 still enhanced cisplatin-induced cytotoxicity. It was concluded that the ROCK inhibitor enhances cisplatin-induced cytotoxicity through FAK suppression-independent mechanism(s). These observations raise the possibility that the inhibition of the ROCK-mediated signal enhances the effect of anti-cancer agents in addition to its antimetastatic property.

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Copy and paste a formatted citation
Spandidos Publications style
Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E, Shimizu E, et al: Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. Int J Oncol 23: 1079-1085, 2003.
APA
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H. ... Shimizu, E. (2003). Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. International Journal of Oncology, 23, 1079-1085. https://doi.org/10.3892/ijo.23.4.1079
MLA
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Yasuda, K., Gutkind, J. S., Hitsuda, Y., Shimizu, E."Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells". International Journal of Oncology 23.4 (2003): 1079-1085.
Chicago
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Yasuda, K., Gutkind, J. S., Hitsuda, Y., Shimizu, E."Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells". International Journal of Oncology 23, no. 4 (2003): 1079-1085. https://doi.org/10.3892/ijo.23.4.1079
Copy and paste a formatted citation
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Spandidos Publications style
Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E, Shimizu E, et al: Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. Int J Oncol 23: 1079-1085, 2003.
APA
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H. ... Shimizu, E. (2003). Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. International Journal of Oncology, 23, 1079-1085. https://doi.org/10.3892/ijo.23.4.1079
MLA
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Yasuda, K., Gutkind, J. S., Hitsuda, Y., Shimizu, E."Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells". International Journal of Oncology 23.4 (2003): 1079-1085.
Chicago
Igishi, T., Mikami, M., Murakami, K., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Yasuda, K., Gutkind, J. S., Hitsuda, Y., Shimizu, E."Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells". International Journal of Oncology 23, no. 4 (2003): 1079-1085. https://doi.org/10.3892/ijo.23.4.1079
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