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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2003 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 23 Issue 4

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Article

Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines

  • Authors:
    • Takemi Otsuki
    • Junichi Kurebayashi
    • Sumiko Ohkubo
    • Masako Uno
    • Tomohiro Fujii
    • Haruko Sakaguchi
    • Tamayo Hatayama
    • Akiko Takata
    • Takayuki Tsujioka
    • Takashi Sugihara
    • Fuminori Hyodoh

  • View Affiliations / Copyright

    Affiliations: Department of Hygiene, Kawasaki Medical School, Okayama 701-0192, Japan. takemi@med.kawasaki-m.ac.jp
  • Pages: 1135-1141
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijo.23.4.1135
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Abstract

We have recently studied expression of estrogen receptors and the growth inhibitory effects of antiestrogens on human myeloma cells. In myeloma chemotherapy, Antiestrogens in combination with other chemotherapeutic agents, may have applications in which melphalan/predonisolone still remains the standard treatment. In this study, we examined expression of HER family molecules in myeloma cells to clarify the possible usage of anti-HER2-monoclonal antibody in the treatment of myeloma. Although the mRNA levels of HER family genes analyzed by RT-PCR were significantly lower in myeloma cells than breast cancer cells, some cell lines expressed a certain amount of HER2 and HER4 proteins. In addition, an anti-HER2 monoclonal antibody, rhumAbHER2, caused significant growth inhibition in six out of eight myeloma cell lines studied and these inhibitory effects were similar to those in the breast cancer cells studied previously. The rhumAbHER2 induced up-regulation of p21 family CDK-Is (cyclin dependent kinase inhibitors) and down-regulation of VEGF genes. Moreover, combination treatment with antiestrogen had an additive growth inhibitory effect. Such analyses may provide for use of rhumAbHER2 in myeloma treatment for the future.

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Copy and paste a formatted citation
Spandidos Publications style
Otsuki T, Kurebayashi J, Ohkubo S, Uno M, Fujii T, Sakaguchi H, Hatayama T, Takata A, Tsujioka T, Sugihara T, Sugihara T, et al: Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines. Int J Oncol 23: 1135-1141, 2003.
APA
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H. ... Hyodoh, F. (2003). Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines. International Journal of Oncology, 23, 1135-1141. https://doi.org/10.3892/ijo.23.4.1135
MLA
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H., Hatayama, T., Takata, A., Tsujioka, T., Sugihara, T., Hyodoh, F."Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines". International Journal of Oncology 23.4 (2003): 1135-1141.
Chicago
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H., Hatayama, T., Takata, A., Tsujioka, T., Sugihara, T., Hyodoh, F."Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines". International Journal of Oncology 23, no. 4 (2003): 1135-1141. https://doi.org/10.3892/ijo.23.4.1135
Copy and paste a formatted citation
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Spandidos Publications style
Otsuki T, Kurebayashi J, Ohkubo S, Uno M, Fujii T, Sakaguchi H, Hatayama T, Takata A, Tsujioka T, Sugihara T, Sugihara T, et al: Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines. Int J Oncol 23: 1135-1141, 2003.
APA
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H. ... Hyodoh, F. (2003). Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines. International Journal of Oncology, 23, 1135-1141. https://doi.org/10.3892/ijo.23.4.1135
MLA
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H., Hatayama, T., Takata, A., Tsujioka, T., Sugihara, T., Hyodoh, F."Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines". International Journal of Oncology 23.4 (2003): 1135-1141.
Chicago
Otsuki, T., Kurebayashi, J., Ohkubo, S., Uno, M., Fujii, T., Sakaguchi, H., Hatayama, T., Takata, A., Tsujioka, T., Sugihara, T., Hyodoh, F."Expression of HER family receptors and effects of anti-HER2-antibody on human myeloma cell lines". International Journal of Oncology 23, no. 4 (2003): 1135-1141. https://doi.org/10.3892/ijo.23.4.1135
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