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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2003 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 23 Issue 4

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Article

Difference in gene expression profile in breast epithelial cells from women with different reproductive history

  • Authors:
    • Shanchun Guo
    • Irma H. Russo
    • Jose Russo

  • View Affiliations / Copyright

    Affiliations: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
  • Pages: 933-941
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijo.23.4.933
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Abstract

The present work was aimed to determine the genomic signature between the undifferentiated lobule type 1 (Lob 1) of the nulliparous women's breast, and the well differentiated lobule type 3 (Lob 3) of the parous women's breast. This study was performed using the RNA obtained from primary cultures of Lob 1 from 3 nulliparous women and Lob 3 of 3 parous pre-menopausal women, and hybridized to cDNA array membranes that contain 1,176 human genes (Clontech Human Cancer 1,2 array). Lob 3 has a gene expression profile significantly different from that of Lob 1. Lob 3 showed 47 genes differentially expressed (>5-fold) when compared with those in Lob 1. Among these genes, RhoE gene is amplified 9.44- fold in the Lob 3 of the parous breast. Other genes such as protein tyrosine phosphatase (PPTPCAAX1 or PRL-1), insulin-like growth factor binding protein-3 (IGFBP-3) and lipocalin 2, are also over expressed in Lob 3 of pre menopausal women. We have confirmed the differential expression of a number of genes using semi- quantitative RT-PCR and immunocytochemical methods. The results indicate that differentially expressed genes occur during normal human breast lobular differentiation and these changes might persistently modify the genomic signature of the breast epithelia.

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Copy and paste a formatted citation
Spandidos Publications style
Guo S, Russo IH and Russo J: Difference in gene expression profile in breast epithelial cells from women with different reproductive history. Int J Oncol 23: 933-941, 2003.
APA
Guo, S., Russo, I.H., & Russo, J. (2003). Difference in gene expression profile in breast epithelial cells from women with different reproductive history. International Journal of Oncology, 23, 933-941. https://doi.org/10.3892/ijo.23.4.933
MLA
Guo, S., Russo, I. H., Russo, J."Difference in gene expression profile in breast epithelial cells from women with different reproductive history". International Journal of Oncology 23.4 (2003): 933-941.
Chicago
Guo, S., Russo, I. H., Russo, J."Difference in gene expression profile in breast epithelial cells from women with different reproductive history". International Journal of Oncology 23, no. 4 (2003): 933-941. https://doi.org/10.3892/ijo.23.4.933
Copy and paste a formatted citation
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Spandidos Publications style
Guo S, Russo IH and Russo J: Difference in gene expression profile in breast epithelial cells from women with different reproductive history. Int J Oncol 23: 933-941, 2003.
APA
Guo, S., Russo, I.H., & Russo, J. (2003). Difference in gene expression profile in breast epithelial cells from women with different reproductive history. International Journal of Oncology, 23, 933-941. https://doi.org/10.3892/ijo.23.4.933
MLA
Guo, S., Russo, I. H., Russo, J."Difference in gene expression profile in breast epithelial cells from women with different reproductive history". International Journal of Oncology 23.4 (2003): 933-941.
Chicago
Guo, S., Russo, I. H., Russo, J."Difference in gene expression profile in breast epithelial cells from women with different reproductive history". International Journal of Oncology 23, no. 4 (2003): 933-941. https://doi.org/10.3892/ijo.23.4.933
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