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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2003 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 23 Issue 4

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Article

Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway

  • Authors:
    • In-Chul Park
    • Myung-Jin Park
    • Sang-Hyeok Woo
    • Hyung-Chahn Lee
    • Sungkwan An
    • Ho-Shin Gwak
    • Seung-Hoon Lee
    • Seok-Il Hong
    • Ill-Ju Bae
    • Kang Moon Seo
    • Chang Hun Rhee

  • View Affiliations / Copyright

    Affiliations: Laboratory of Cell Biology, Korea Institute of Radiological and Medical Sciences, Seoul 139-240, South Korea
  • Pages: 943-948
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijo.23.4.943
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Abstract

In the present study, we investigated the effect of tetraarsenic oxide (As4O6, 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane) upon induction of apoptosis in arsenic trioxide (diarsenic oxide, As2O3) resistant U937 leukemic cells. As4O6 induced apoptosis in U937 leukemic cells at much lower concentrations than As2O3 via an early increase of cellular reactive oxygen species (ROS), and a decrease in cellular mitochondrial membrane potential, followed by cytochrome c release and caspase-3 activation. As4O6 generated ROS and induced caspase-3 activation more potently than As2O3 in U937 cells. Incubation of the cells with N-acetyl-L-cysteine and catalase resulted in significant suppression of As4O6-induced apoptotic cell death. These results show that the generation of ROS leads to the consequences associated with apoptosis induced by As4O6. In conclusion, As4O6 might be a new arsenic compound which may induce apoptosis in U937 leukemic cells by activating unique apoptotic signaling mediated by ROS more potently than As2O3, and deserves further evaluation.

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Copy and paste a formatted citation
Spandidos Publications style
Park I, Park M, Woo S, Lee H, An S, Gwak H, Lee S, Hong S, Bae I, Seo KM, Seo KM, et al: Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. Int J Oncol 23: 943-948, 2003.
APA
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H. ... Rhee, C.H. (2003). Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. International Journal of Oncology, 23, 943-948. https://doi.org/10.3892/ijo.23.4.943
MLA
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H., Lee, S., Hong, S., Bae, I., Seo, K. M., Rhee, C. H."Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway". International Journal of Oncology 23.4 (2003): 943-948.
Chicago
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H., Lee, S., Hong, S., Bae, I., Seo, K. M., Rhee, C. H."Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway". International Journal of Oncology 23, no. 4 (2003): 943-948. https://doi.org/10.3892/ijo.23.4.943
Copy and paste a formatted citation
x
Spandidos Publications style
Park I, Park M, Woo S, Lee H, An S, Gwak H, Lee S, Hong S, Bae I, Seo KM, Seo KM, et al: Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. Int J Oncol 23: 943-948, 2003.
APA
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H. ... Rhee, C.H. (2003). Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway. International Journal of Oncology, 23, 943-948. https://doi.org/10.3892/ijo.23.4.943
MLA
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H., Lee, S., Hong, S., Bae, I., Seo, K. M., Rhee, C. H."Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway". International Journal of Oncology 23.4 (2003): 943-948.
Chicago
Park, I., Park, M., Woo, S., Lee, H., An, S., Gwak, H., Lee, S., Hong, S., Bae, I., Seo, K. M., Rhee, C. H."Tetraarsenic oxide induces apoptosis in U937 leukemic cells through a reactive oxygen species-dependent pathway". International Journal of Oncology 23, no. 4 (2003): 943-948. https://doi.org/10.3892/ijo.23.4.943
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