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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 23 Issue 6

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Article

Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation

  • Authors:
    • Juergen-Theodor Fraenzer
    • Huiqi Pan
    • Lauro Minimo
    • George M. Smith
    • Dan Knauer
    • Gene Hung

  • View Affiliations / Copyright

    Affiliations: ENT-Clinic, Molecular Neurobiology, University of Tuebingen, 72076 Tuebingen, Germany
  • Pages: 1493-1500
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1493
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Abstract

The loss of NF2 gene function leads to vestibular nerve schwannoma formation in humans. The NF2 gene product, Merlin/Schwannomin, has recently been found to interact with the two PDZ domains containing protein EBP50/NHE-RF, which is itself known to interact with the PDGF receptor (PDGFR) in several cell types. In this study, an up-regulation of both PDGFR and EBP50/NHE-RF, and an interaction of both proteins were found in primary human schwannoma tissue. Furthermore, using an adenoviral vector mediated gene transfer technique, changes in the phenotypic characteristics after NF2 gene restoration in a newly established NF2 gene-mutated human schwannoma cell line (HEI 193) were investigated. The overexpression of Merlin/Schwannomin in HEI 193 led to an inhibition of cell proliferation under serum-free conditions. Upon PDGF stimulation in culture, Merlin/Schwannomin appeared to inhibit the activation of the MAPK and PI3K signaling pathways, impinging on the phosphorylation of Erk 1/2 and Akt, respectively. The data also show that PDGFR is more rapidly internalized by the schwannoma cells overexpressing NF2. Therefore, this process is suggested as a model for a mechanism of Merlin/Schwannomin tumor suppressor function, which intermediates acceleration of the cell surface growth factor degradation.

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Copy and paste a formatted citation
Spandidos Publications style
Fraenzer J, Pan H, Minimo L, Smith GM, Knauer D and Hung G: Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. Int J Oncol 23: 1493-1500, 2003.
APA
Fraenzer, J., Pan, H., Minimo, L., Smith, G.M., Knauer, D., & Hung, G. (2003). Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. International Journal of Oncology, 23, 1493-1500. https://doi.org/10.3892/ijo.23.6.1493
MLA
Fraenzer, J., Pan, H., Minimo, L., Smith, G. M., Knauer, D., Hung, G."Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation". International Journal of Oncology 23.6 (2003): 1493-1500.
Chicago
Fraenzer, J., Pan, H., Minimo, L., Smith, G. M., Knauer, D., Hung, G."Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation". International Journal of Oncology 23, no. 6 (2003): 1493-1500. https://doi.org/10.3892/ijo.23.6.1493
Copy and paste a formatted citation
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Spandidos Publications style
Fraenzer J, Pan H, Minimo L, Smith GM, Knauer D and Hung G: Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. Int J Oncol 23: 1493-1500, 2003.
APA
Fraenzer, J., Pan, H., Minimo, L., Smith, G.M., Knauer, D., & Hung, G. (2003). Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. International Journal of Oncology, 23, 1493-1500. https://doi.org/10.3892/ijo.23.6.1493
MLA
Fraenzer, J., Pan, H., Minimo, L., Smith, G. M., Knauer, D., Hung, G."Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation". International Journal of Oncology 23.6 (2003): 1493-1500.
Chicago
Fraenzer, J., Pan, H., Minimo, L., Smith, G. M., Knauer, D., Hung, G."Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation". International Journal of Oncology 23, no. 6 (2003): 1493-1500. https://doi.org/10.3892/ijo.23.6.1493
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