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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 23 Issue 6

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Article

Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene

  • Authors:
    • Yong-Soo Kim
    • Jihwan Song
    • Yukyung Kim
    • In-Ok Kim
    • Incheol Kang
    • Kwang-Hyun Baek

  • View Affiliations / Copyright

    Affiliations: Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul, Korea
  • Pages: 1515-1519
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1515
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Abstract

We recently isolated a few mammalian homologue of Drosophila lethal giant larvae (lgl) recessive oncogene, suggesting that there is functional conservation among proteins of this family. The comparison of amino acid sequence for mgl-1 with other lgl family members using the clustal method showed that they are highly homologous. Therefore, we investigated the biological function of mgl-1, a mouse orthologue of lgl, in the absence of Saccharomyces cerevisiae Sop1 and Sop2, the yeast homologues of the lgl recessive oncogene. Functional analysis showed that the expression of mgl-1 cDNA partially restored salt tolerance in yeast, indicating the evolutionary conservation of lgl family members. Since the developmental expression profile of mgl-1 has not been elucidated, the temporal and spatial expression patterns of mouse mgl-1 during early embryonic development were analyzed. The temporal expression analysis revealed that mgl-1 is expressed throughout embryonic development from days E4.5 to E18.5 with the strong expression at E10.5. The analysis of spatial expression showed that mgl-1 mRNA is detected in CNS, craniofacial region, eyes, limbs, and the gut.

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Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Song J, Kim Y, Kim I, Kang I and Baek K: Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Int J Oncol 23: 1515-1519, 2003.
APA
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., & Baek, K. (2003). Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. International Journal of Oncology, 23, 1515-1519. https://doi.org/10.3892/ijo.23.6.1515
MLA
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., Baek, K."Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene". International Journal of Oncology 23.6 (2003): 1515-1519.
Chicago
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., Baek, K."Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene". International Journal of Oncology 23, no. 6 (2003): 1515-1519. https://doi.org/10.3892/ijo.23.6.1515
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Song J, Kim Y, Kim I, Kang I and Baek K: Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Int J Oncol 23: 1515-1519, 2003.
APA
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., & Baek, K. (2003). Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. International Journal of Oncology, 23, 1515-1519. https://doi.org/10.3892/ijo.23.6.1515
MLA
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., Baek, K."Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene". International Journal of Oncology 23.6 (2003): 1515-1519.
Chicago
Kim, Y., Song, J., Kim, Y., Kim, I., Kang, I., Baek, K."Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene". International Journal of Oncology 23, no. 6 (2003): 1515-1519. https://doi.org/10.3892/ijo.23.6.1515
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