Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer

  • Authors:
    • Adalberto Abraão Siufi
    • Ismael Dale Cotrim G. Da Silva
    • Rita De Cassia M. Dardes
    • Luiz Carlos Takita
    • Geraldo Rodrigues De Lima
    • Wagner José Gonçalves
  • View Affiliations

  • Published online on: December 1, 2003     https://doi.org/10.3892/ijo.23.6.1545
  • Pages: 1545-1551
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Abstract

The cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. Fifty-three pre- and post-tamoxifen treatment endometrium samples were examined immunohistochemically using p27 antibody. Tamoxifen therapy (20 mg/day) for 60 days increased the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. We conclude that tamoxifen therapy does not seem to be directly involved in the carcinogenesis of endometrial carcinoma since the expression of p27 is not decreased.

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December 2003
Volume 23 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Siufi AA, Cotrim G. Da Silva ID, De Cassia M. Dardes R, Takita LC, Rodrigues De Lima G and Gonçalves WJ: Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. Int J Oncol 23: 1545-1551, 2003.
APA
Siufi, A.A., Cotrim G. Da Silva, I.D., De Cassia M. Dardes, R., Takita, L.C., Rodrigues De Lima, G., & Gonçalves, W.J. (2003). Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. International Journal of Oncology, 23, 1545-1551. https://doi.org/10.3892/ijo.23.6.1545
MLA
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23.6 (2003): 1545-1551.
Chicago
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23, no. 6 (2003): 1545-1551. https://doi.org/10.3892/ijo.23.6.1545