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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 23 Issue 6

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Article

Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer

  • Authors:
    • Adalberto Abraão Siufi
    • Ismael Dale Cotrim G. Da Silva
    • Rita De Cassia M. Dardes
    • Luiz Carlos Takita
    • Geraldo Rodrigues De Lima
    • Wagner José Gonçalves

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Federal University of Mato Grosso, São Paulo, Brazil
  • Pages: 1545-1551
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1545
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Abstract

The cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. Fifty-three pre- and post-tamoxifen treatment endometrium samples were examined immunohistochemically using p27 antibody. Tamoxifen therapy (20 mg/day) for 60 days increased the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. We conclude that tamoxifen therapy does not seem to be directly involved in the carcinogenesis of endometrial carcinoma since the expression of p27 is not decreased.

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Copy and paste a formatted citation
Spandidos Publications style
Siufi AA, Cotrim G. Da Silva ID, De Cassia M. Dardes R, Takita LC, Rodrigues De Lima G and Gonçalves WJ: Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. Int J Oncol 23: 1545-1551, 2003.
APA
Siufi, A.A., Cotrim G. Da Silva, I.D., De Cassia M. Dardes, R., Takita, L.C., Rodrigues De Lima, G., & Gonçalves, W.J. (2003). Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. International Journal of Oncology, 23, 1545-1551. https://doi.org/10.3892/ijo.23.6.1545
MLA
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23.6 (2003): 1545-1551.
Chicago
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23, no. 6 (2003): 1545-1551. https://doi.org/10.3892/ijo.23.6.1545
Copy and paste a formatted citation
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Spandidos Publications style
Siufi AA, Cotrim G. Da Silva ID, De Cassia M. Dardes R, Takita LC, Rodrigues De Lima G and Gonçalves WJ: Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. Int J Oncol 23: 1545-1551, 2003.
APA
Siufi, A.A., Cotrim G. Da Silva, I.D., De Cassia M. Dardes, R., Takita, L.C., Rodrigues De Lima, G., & Gonçalves, W.J. (2003). Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer. International Journal of Oncology, 23, 1545-1551. https://doi.org/10.3892/ijo.23.6.1545
MLA
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23.6 (2003): 1545-1551.
Chicago
Siufi, A. A., Cotrim G. Da Silva, I. D., De Cassia M. Dardes, R., Takita, L. C., Rodrigues De Lima, G., Gonçalves, W. J."Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer". International Journal of Oncology 23, no. 6 (2003): 1545-1551. https://doi.org/10.3892/ijo.23.6.1545
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