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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 23 Issue 6

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Article

Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells

  • Authors:
    • Yung Hyun Choi
    • Kyu Ri Kong
    • Young-Ae Kim
    • Keun-Ok Jung
    • Jeong-Ha Kil
    • Sook-Hee Rhee
    • Kun-Young Park

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Dong-Eui University College of Oriental Medicine, Busan 614-052, Korea. choiyh@dongeui.ac.kr
  • Pages: 1657-1662
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1657
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Abstract

β-sitosterol, a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. The purpose of the present study was to examine the effect of β-sitosterol on the growth of HT116 human colon cancer cells. Treatment with β-sitosterol resulted in a dose-dependent growth inhibition coupled with the characteristic morphological features of apoptosis and with the increase of a sub-G1 cell population. Apoptosis-inducing concentrations of β-sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase. In addition, β-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol. β-sitosterol treatment also inhibited the expression of cIAP-1 without significant changes in the level of cIAP-2. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of β-sitosterol.

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Copy and paste a formatted citation
Spandidos Publications style
Choi YH, Kong KR, Kim Y, Jung K, Kil J, Rhee S and Park K: Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells. Int J Oncol 23: 1657-1662, 2003.
APA
Choi, Y.H., Kong, K.R., Kim, Y., Jung, K., Kil, J., Rhee, S., & Park, K. (2003). Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells. International Journal of Oncology, 23, 1657-1662. https://doi.org/10.3892/ijo.23.6.1657
MLA
Choi, Y. H., Kong, K. R., Kim, Y., Jung, K., Kil, J., Rhee, S., Park, K."Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells". International Journal of Oncology 23.6 (2003): 1657-1662.
Chicago
Choi, Y. H., Kong, K. R., Kim, Y., Jung, K., Kil, J., Rhee, S., Park, K."Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells". International Journal of Oncology 23, no. 6 (2003): 1657-1662. https://doi.org/10.3892/ijo.23.6.1657
Copy and paste a formatted citation
x
Spandidos Publications style
Choi YH, Kong KR, Kim Y, Jung K, Kil J, Rhee S and Park K: Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells. Int J Oncol 23: 1657-1662, 2003.
APA
Choi, Y.H., Kong, K.R., Kim, Y., Jung, K., Kil, J., Rhee, S., & Park, K. (2003). Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells. International Journal of Oncology, 23, 1657-1662. https://doi.org/10.3892/ijo.23.6.1657
MLA
Choi, Y. H., Kong, K. R., Kim, Y., Jung, K., Kil, J., Rhee, S., Park, K."Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells". International Journal of Oncology 23.6 (2003): 1657-1662.
Chicago
Choi, Y. H., Kong, K. R., Kim, Y., Jung, K., Kil, J., Rhee, S., Park, K."Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells". International Journal of Oncology 23, no. 6 (2003): 1657-1662. https://doi.org/10.3892/ijo.23.6.1657
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