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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2004 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 24 Issue 4

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Article

Imprinting status of DLK1 gene in brain tumors and lymphomas

  • Authors:
    • Dong Yin
    • Dong Xie
    • Sven De Vos
    • Gentao Liu
    • Carl W. Miller
    • Keith L. Black
    • H. Phillip Koeffler

  • View Affiliations / Copyright

    Affiliations: Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA. dong.yin@cshs.org
  • Pages: 1011-1015
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/ijo.24.4.1011
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Abstract

DLK1 and GTL2 are reciprocally imprinted genes on human chromosome 14q32. DLK1 encodes a transmembrane protein that is a paternally expressed gene. The maternally expressed GTL2 allele encodes a non-translated RNA. Many of features of DLK1/GTL2 are remarkably similar to those of the prototypical IGF2/H19 reciprocally imprinted gene pair. Imprinting status of IGF2 has been studied in many types of tumors, and loss of imprinting (LOI) leads to biallelic expression of IGF2 in most of these tumors. The imprinting status of DLK1 has seldom been investigated in clinical tumor samples. We examined whether DLK1 was imprinted in brain tumors and lymphomas by analyzing a single nucleotide polymorphism (SNP), rs1802710. Analysis of 47 brain tumors and 55 lymphomas found that 23 and 29 of them were heterozygous for rs1802710, respectively. Monoallelic expression of DLK1 was detected in the heterozygous samples. These data show that imprinting of DLK1 is maintained in brain tumors and lymphomas, even though the DLK1 gene is very analogous to the IGF2 gene in its DNA structure and regulation. Also, the high frequency of heterozygosity (about 50%) showed that the polymorphic site that we chose is a good genomic marker for imprinting studies of the DLK1 gene in additional tumor types.

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Copy and paste a formatted citation
Spandidos Publications style
Yin D, Xie D, De Vos S, Liu G, Miller CW, Black KL and Koeffler HP: Imprinting status of DLK1 gene in brain tumors and lymphomas. Int J Oncol 24: 1011-1015, 2004.
APA
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C.W., Black, K.L., & Koeffler, H.P. (2004). Imprinting status of DLK1 gene in brain tumors and lymphomas. International Journal of Oncology, 24, 1011-1015. https://doi.org/10.3892/ijo.24.4.1011
MLA
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C. W., Black, K. L., Koeffler, H. P."Imprinting status of DLK1 gene in brain tumors and lymphomas". International Journal of Oncology 24.4 (2004): 1011-1015.
Chicago
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C. W., Black, K. L., Koeffler, H. P."Imprinting status of DLK1 gene in brain tumors and lymphomas". International Journal of Oncology 24, no. 4 (2004): 1011-1015. https://doi.org/10.3892/ijo.24.4.1011
Copy and paste a formatted citation
x
Spandidos Publications style
Yin D, Xie D, De Vos S, Liu G, Miller CW, Black KL and Koeffler HP: Imprinting status of DLK1 gene in brain tumors and lymphomas. Int J Oncol 24: 1011-1015, 2004.
APA
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C.W., Black, K.L., & Koeffler, H.P. (2004). Imprinting status of DLK1 gene in brain tumors and lymphomas. International Journal of Oncology, 24, 1011-1015. https://doi.org/10.3892/ijo.24.4.1011
MLA
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C. W., Black, K. L., Koeffler, H. P."Imprinting status of DLK1 gene in brain tumors and lymphomas". International Journal of Oncology 24.4 (2004): 1011-1015.
Chicago
Yin, D., Xie, D., De Vos, S., Liu, G., Miller, C. W., Black, K. L., Koeffler, H. P."Imprinting status of DLK1 gene in brain tumors and lymphomas". International Journal of Oncology 24, no. 4 (2004): 1011-1015. https://doi.org/10.3892/ijo.24.4.1011
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