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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2004 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 24 Issue 4

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Article

Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors

  • Authors:
    • On Hee Kim
    • Jun Hee Lim
    • Kyung Jin Woo
    • Young-Ho Kim
    • Ing-Nyol Jin
    • Sang Tae Han
    • Jong-Wook Park
    • Taeg Kyu Kwon

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Medicine, Keimyung University, Taegu 700-712, South Korea
  • Pages: 935-941
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/ijo.24.4.935
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Abstract

Ubiquitin-mediated protein degradation in vertebrates has been implicated in cell cycle control. In this report we explored the effects of proteasome inhibitors (MG132, lactacystin and ALLN) on cell cycle distribution. Colorectal carcinoma HCT116 cells were treated with proteasome inhibitor MG132. The results showed that MG132 inhibited cell proliferation in a dose-dependent manner. MG132 arrested HCT116 cells at G2/M phase, which was associated with drug-induced blockade of p53 degradation and/or induction of p53-related gene expression along with the accumulation of cyclin B, cyclin A and p21. MG132 treated HCT116 (wild-type) had a similar cell cycle distribution as the MG132 treated HCT116 (p53−/−) and HCT116 (p21−/−) cells, suggesting that p53 and p21 may not be essential for MG132-induced G2/M phase arrest. The release experiments from nocodazole-induced mitotic phase cells indicated that MG132 inhibits the proliferation of HCT116 cells via arrest in the G2 phase. In addition, when HCT116 cells were exposed to combination of sodium butyrate and MG132 enhanced cell growth inhibition and induction of apoptosis were observed.

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Copy and paste a formatted citation
Spandidos Publications style
Kim OH, Lim JH, Woo KJ, Kim Y, Jin I, Han ST, Park J and Kwon TK: Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. Int J Oncol 24: 935-941, 2004.
APA
Kim, O.H., Lim, J.H., Woo, K.J., Kim, Y., Jin, I., Han, S.T. ... Kwon, T.K. (2004). Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. International Journal of Oncology, 24, 935-941. https://doi.org/10.3892/ijo.24.4.935
MLA
Kim, O. H., Lim, J. H., Woo, K. J., Kim, Y., Jin, I., Han, S. T., Park, J., Kwon, T. K."Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors". International Journal of Oncology 24.4 (2004): 935-941.
Chicago
Kim, O. H., Lim, J. H., Woo, K. J., Kim, Y., Jin, I., Han, S. T., Park, J., Kwon, T. K."Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors". International Journal of Oncology 24, no. 4 (2004): 935-941. https://doi.org/10.3892/ijo.24.4.935
Copy and paste a formatted citation
x
Spandidos Publications style
Kim OH, Lim JH, Woo KJ, Kim Y, Jin I, Han ST, Park J and Kwon TK: Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. Int J Oncol 24: 935-941, 2004.
APA
Kim, O.H., Lim, J.H., Woo, K.J., Kim, Y., Jin, I., Han, S.T. ... Kwon, T.K. (2004). Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. International Journal of Oncology, 24, 935-941. https://doi.org/10.3892/ijo.24.4.935
MLA
Kim, O. H., Lim, J. H., Woo, K. J., Kim, Y., Jin, I., Han, S. T., Park, J., Kwon, T. K."Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors". International Journal of Oncology 24.4 (2004): 935-941.
Chicago
Kim, O. H., Lim, J. H., Woo, K. J., Kim, Y., Jin, I., Han, S. T., Park, J., Kwon, T. K."Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors". International Journal of Oncology 24, no. 4 (2004): 935-941. https://doi.org/10.3892/ijo.24.4.935
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