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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2004 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2004 Volume 25 Issue 5

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Article

Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice

  • Authors:
    • So Tsuboi
    • Kazuhiro Nouso
    • Yasuko Tomono
    • Seishi Nagamori
    • Ichiro Naito
    • Tsunakazu Watanabe
    • Koji Manabe
    • Hiroyuki Ohmori
    • Harushige Nakatsukasa
    • Masahiro Miyazaki
    • Toshihiro Higashi
    • Yasushi Shiratori
    • Masayoshi Namba
    • Yoshifumi Ninomiya
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, Shigei Medical Research Hospital, Okayama 701-0202, Japan. tsuboi@shigei.or.jp
  • Pages: 1267-1271
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/ijo.25.5.1267
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Abstract

Endostatin, a fragment of collagen XVIII, inhibits angiogenesis in tumors, and is expected to become a new anticancer drug. However, its effectiveness is still controversial, because some researchers failed to reproduce the same marked regression of tumors by the peptide. We gave anti-endostatin monoclonal antibody, designated as CH18B, to nude mice transplanted with human hepatocellular carcinoma cells (JHH-1 line) that endogenously produced endostatin from collagen XVIII secreted by the cells themselves. As a result, CH18B promoted tumor angiogenesis by inhibiting endostatin activity in the tumor and subsequently increased tumor mass by preventing cancer cells from undergoing apoptosis. But the antibody itself did not stimulate proliferation of the tumor cells. Our present experimental procedure, the use of anti-endostatin antibody, definitely solved the question whether endostatin might exert its anticancer activity.

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Copy and paste a formatted citation
Spandidos Publications style
Tsuboi S, Nouso K, Tomono Y, Nagamori S, Naito I, Watanabe T, Manabe K, Ohmori H, Nakatsukasa H, Miyazaki M, Miyazaki M, et al: Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice. Int J Oncol 25: 1267-1271, 2004.
APA
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T. ... Ninomiya, Y. (2004). Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice. International Journal of Oncology, 25, 1267-1271. https://doi.org/10.3892/ijo.25.5.1267
MLA
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T., Manabe, K., Ohmori, H., Nakatsukasa, H., Miyazaki, M., Higashi, T., Shiratori, Y., Namba, M., Ninomiya, Y."Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice". International Journal of Oncology 25.5 (2004): 1267-1271.
Chicago
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T., Manabe, K., Ohmori, H., Nakatsukasa, H., Miyazaki, M., Higashi, T., Shiratori, Y., Namba, M., Ninomiya, Y."Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice". International Journal of Oncology 25, no. 5 (2004): 1267-1271. https://doi.org/10.3892/ijo.25.5.1267
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuboi S, Nouso K, Tomono Y, Nagamori S, Naito I, Watanabe T, Manabe K, Ohmori H, Nakatsukasa H, Miyazaki M, Miyazaki M, et al: Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice. Int J Oncol 25: 1267-1271, 2004.
APA
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T. ... Ninomiya, Y. (2004). Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice. International Journal of Oncology, 25, 1267-1271. https://doi.org/10.3892/ijo.25.5.1267
MLA
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T., Manabe, K., Ohmori, H., Nakatsukasa, H., Miyazaki, M., Higashi, T., Shiratori, Y., Namba, M., Ninomiya, Y."Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice". International Journal of Oncology 25.5 (2004): 1267-1271.
Chicago
Tsuboi, S., Nouso, K., Tomono, Y., Nagamori, S., Naito, I., Watanabe, T., Manabe, K., Ohmori, H., Nakatsukasa, H., Miyazaki, M., Higashi, T., Shiratori, Y., Namba, M., Ninomiya, Y."Anti-endostatin monoclonal antibody enhances growth of human hepatocellular carcinoma cells by inhibiting activity of endostatin secreted by the transplanted cells in nude mice". International Journal of Oncology 25, no. 5 (2004): 1267-1271. https://doi.org/10.3892/ijo.25.5.1267
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