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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2005 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2005 Volume 26 Issue 5

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Article

Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells

  • Authors:
    • Naoki Koizumi
    • Etsuro Hatano
    • Takashi Nitta
    • Masaharu Tada
    • Nobuko Harada
    • Kojiro Taura
    • Iwao Ikai
    • Yasuyuki Shimahara

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
  • Pages: 1301-1306
    |
    Published online on: May 1, 2005
       https://doi.org/10.3892/ijo.26.5.1301
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Abstract

Hepatocellular carcinoma (HCC) is a common malignancy and often resistant to chemotherapy. Many chemotherapy regimens have been tried to control advanced HCC, but have produced a low response rate and no clear impact. CPT-11, a derivative of camptothecin, works as type-I DNA topoisomerase inhibitor and showed a major objective response rate in patients with metastatic colorectal cancer. In this study, the mechanism underlying chemo-resistance to SN-38, an active form of CPT-11, in HCC was investigated in relation to anti-apoptotic pathways NF-κB and PI3K/Akt. Hep3B was the most resistant to SN-38 among three hepatoma cell lines. NF-κB was constitutively activated in Hep3B, and SN-38 further enhanced the nuclear translocation of NF-κB. However, inactivation of NF-κB by adenovirus expressing IκB super-repressor or MG-132, proteasome inhibitor, did not sensitize Hep3B to SN-38-induced apoptosis. On the other hand, SN-38 phosphorylated Akt and pretreatment with PI3K inhibitors increased SN-38-induced apoptosis, indicating that resistance to SN-38 in Hep3B occurs partly through the PI3K/Akt not the NF-κB pathway. Blocking of PI3K/Akt may thus be helpful for overcoming chemo-resistance of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Koizumi N, Hatano E, Nitta T, Tada M, Harada N, Taura K, Ikai I and Shimahara Y: Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells. Int J Oncol 26: 1301-1306, 2005.
APA
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K. ... Shimahara, Y. (2005). Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells. International Journal of Oncology, 26, 1301-1306. https://doi.org/10.3892/ijo.26.5.1301
MLA
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K., Ikai, I., Shimahara, Y."Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells". International Journal of Oncology 26.5 (2005): 1301-1306.
Chicago
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K., Ikai, I., Shimahara, Y."Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells". International Journal of Oncology 26, no. 5 (2005): 1301-1306. https://doi.org/10.3892/ijo.26.5.1301
Copy and paste a formatted citation
x
Spandidos Publications style
Koizumi N, Hatano E, Nitta T, Tada M, Harada N, Taura K, Ikai I and Shimahara Y: Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells. Int J Oncol 26: 1301-1306, 2005.
APA
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K. ... Shimahara, Y. (2005). Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells. International Journal of Oncology, 26, 1301-1306. https://doi.org/10.3892/ijo.26.5.1301
MLA
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K., Ikai, I., Shimahara, Y."Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells". International Journal of Oncology 26.5 (2005): 1301-1306.
Chicago
Koizumi, N., Hatano, E., Nitta, T., Tada, M., Harada, N., Taura, K., Ikai, I., Shimahara, Y."Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells". International Journal of Oncology 26, no. 5 (2005): 1301-1306. https://doi.org/10.3892/ijo.26.5.1301
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