Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation

  • Authors:
    • P. Costelli
    • M. Muscaritoli
    • M. Bossola
    • R. Moore-Carrasco
    • S. Crepaldi
    • G. Grieco
    • R. Autelli
    • G. Bonelli
    • F. Pacelli
    • F. J. Lopez-Soriano
    • J. M. Argilés
    • G. B. Doglietto
    • F. M. Baccino
    • F. Rossi Fanelli
  • View Affiliations

  • Published online on: June 1, 2005     https://doi.org/10.3892/ijo.26.6.1663
  • Pages: 1663-1668
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Abstract

Cachexia is a syndrome characterized by profound skeletal muscle wasting that frequently complicates malignancies. A number of studies indicate that protein hypercatabolism, largely mediated by classical hormones and cytokines, is the major component of muscle depletion. Impaired regeneration has been suggested to contribute to the reduction of muscle size. In particular, it has been shown that the expression of MyoD, a muscle-specific transcription factor, is down-regulated by cytokines such as TNFα and IFNγ in a NF-κB-dependent posttranscriptional manner. The present study investigated whether modulations of the transcription factor MyoD are associated with the onset of muscle wasting in a well established model of cancer cachexia. Rats bearing the Yoshida AH-130 hepatoma develop a condition of muscle protein hypercatabolism, largely dependent on TNFα bioactivity. In the gastrocnemius of these animals the expression of MyoD was markedly reduced, paralleling the decrease of muscle weight. This pattern is associated with increased nuclear translocation of AP-1, while DNA-binding assays did not detect any change in NF-κB activity. This is the first observation demonstrating that muscle depletion in tumor-bearing rats is associated with a down-regulation of MyoD levels. Although the underlying mechanisms remain to be clarified, this change is compatible with the hypothesis that a reduced expression of molecules involved in the regulation of the regenerative response may concur to muscle wasting in cancer cachexia.

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June 2005
Volume 26 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Costelli P, Muscaritoli M, Bossola M, Moore-Carrasco R, Crepaldi S, Grieco G, Autelli R, Bonelli G, Pacelli F, Lopez-Soriano FJ, Lopez-Soriano FJ, et al: Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation. Int J Oncol 26: 1663-1668, 2005
APA
Costelli, P., Muscaritoli, M., Bossola, M., Moore-Carrasco, R., Crepaldi, S., Grieco, G. ... Rossi Fanelli, F. (2005). Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation. International Journal of Oncology, 26, 1663-1668. https://doi.org/10.3892/ijo.26.6.1663
MLA
Costelli, P., Muscaritoli, M., Bossola, M., Moore-Carrasco, R., Crepaldi, S., Grieco, G., Autelli, R., Bonelli, G., Pacelli, F., Lopez-Soriano, F. J., Argilés, J. M., Doglietto, G. B., Baccino, F. M., Rossi Fanelli, F."Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation". International Journal of Oncology 26.6 (2005): 1663-1668.
Chicago
Costelli, P., Muscaritoli, M., Bossola, M., Moore-Carrasco, R., Crepaldi, S., Grieco, G., Autelli, R., Bonelli, G., Pacelli, F., Lopez-Soriano, F. J., Argilés, J. M., Doglietto, G. B., Baccino, F. M., Rossi Fanelli, F."Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation". International Journal of Oncology 26, no. 6 (2005): 1663-1668. https://doi.org/10.3892/ijo.26.6.1663