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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2005 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2005 Volume 27 Issue 2

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Article

HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model

  • Authors:
    • Rajkumar Savai
    • Ralph Theo Schermuly
    • Robert Voswinckel
    • Aparna Renigunta
    • Bernd Reichmann
    • Bastian Eul
    • Friedrich Grimminger
    • Werner Seeger
    • Frank Rose
    • Jörg Hänze

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine II, Medical School of the Justus-Liebig-University, D-35392 Giessen, Germany
  • Pages: 393-400
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/ijo.27.2.393
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Abstract

The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, employing human lung adenocarcinoma A549 cells. The A549 cells were transfected to overexpress HIF-1α. These cells displayed decreased proliferation, cell-cycle entry, colony formation in soft agar and elevated levels of apoptosis, when compared to control cells transfected with empty vector. The cells were employed in a tumor model by subcutaneous injection into CD-1 nude mice. Persistent overexpression of HIF1α and VEGF was demonstrated in these tumors. The HIF-1α-overexpressing tumors displayed less tumor growth when compared to tumors formed by control cells. Tumors derived from HIF-1α-overexpressing cells revealed an increase in apoptosis when compared to control tumors, in spite of a marked increase in vascular density. We conclude that in lung A549 cells, overexpression of HIF-1α negatively affects tumor growth due to decreased proliferation and increased apoptosis, despite augmented angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Savai R, Schermuly RT, Voswinckel R, Renigunta A, Reichmann B, Eul B, Grimminger F, Seeger W, Rose F, Hänze J, Hänze J, et al: HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model. Int J Oncol 27: 393-400, 2005.
APA
Savai, R., Schermuly, R.T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B. ... Hänze, J. (2005). HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model. International Journal of Oncology, 27, 393-400. https://doi.org/10.3892/ijo.27.2.393
MLA
Savai, R., Schermuly, R. T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B., Grimminger, F., Seeger, W., Rose, F., Hänze, J."HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model". International Journal of Oncology 27.2 (2005): 393-400.
Chicago
Savai, R., Schermuly, R. T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B., Grimminger, F., Seeger, W., Rose, F., Hänze, J."HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model". International Journal of Oncology 27, no. 2 (2005): 393-400. https://doi.org/10.3892/ijo.27.2.393
Copy and paste a formatted citation
x
Spandidos Publications style
Savai R, Schermuly RT, Voswinckel R, Renigunta A, Reichmann B, Eul B, Grimminger F, Seeger W, Rose F, Hänze J, Hänze J, et al: HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model. Int J Oncol 27: 393-400, 2005.
APA
Savai, R., Schermuly, R.T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B. ... Hänze, J. (2005). HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model. International Journal of Oncology, 27, 393-400. https://doi.org/10.3892/ijo.27.2.393
MLA
Savai, R., Schermuly, R. T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B., Grimminger, F., Seeger, W., Rose, F., Hänze, J."HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model". International Journal of Oncology 27.2 (2005): 393-400.
Chicago
Savai, R., Schermuly, R. T., Voswinckel, R., Renigunta, A., Reichmann, B., Eul, B., Grimminger, F., Seeger, W., Rose, F., Hänze, J."HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model". International Journal of Oncology 27, no. 2 (2005): 393-400. https://doi.org/10.3892/ijo.27.2.393
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