Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis

  • Authors:
    • Michael J. Jarzynka
    • Ping Guo
    • Ifat Bar-Joseph
    • Bo Hu
    • Shi-Yuan Cheng
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/ijo.28.2.337
  • Pages: 337-344
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Abstract

Angiogenesis is required for lung cancer growth, which is mediated by various growth factors such as vascular endothelial growth factor (VEGF). Increases in VEGF and angiogenesis have been correlated with poor prognosis and survival in patients with lung cancer. In addition, recent reports show that estradiol and nicotine play important roles in lung tumor initiation and progression. In this report, we demonstrate that estradiol and nicotine exposure enhances the growth of A549 bronchioloalveolar carcinoma xenografts in mice through the stimulation of cell proliferation, VEGF secretion and angiogenesis. We detect a four-fold increase in microvascular density in tumors from mice exposed to estradiol and nicotine compared to control tumors resulting in an increase in tumor growth. Intriguingly, the effects on angiogenesis and tumor growth by the combination of agents were additive when compared to either agent alone. Furthermore, estradiol promotes VEGF secretion from various non-small cell lung carcinoma (NSCLC) cells and this effect is augmented by nicotine in a tumor xenograft model. These results indicate that aside from their roles in promoting cell proliferation, estradiol and nicotine appear to have additive effects on the induction of angiogenesis through the stimulation of VEGF secretion during NSCLC progression.

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February 2006
Volume 28 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Jarzynka MJ, Guo P, Bar-Joseph I, Hu B and Cheng S: Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis. Int J Oncol 28: 337-344, 2006
APA
Jarzynka, M.J., Guo, P., Bar-Joseph, I., Hu, B., & Cheng, S. (2006). Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis. International Journal of Oncology, 28, 337-344. https://doi.org/10.3892/ijo.28.2.337
MLA
Jarzynka, M. J., Guo, P., Bar-Joseph, I., Hu, B., Cheng, S."Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis". International Journal of Oncology 28.2 (2006): 337-344.
Chicago
Jarzynka, M. J., Guo, P., Bar-Joseph, I., Hu, B., Cheng, S."Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis". International Journal of Oncology 28, no. 2 (2006): 337-344. https://doi.org/10.3892/ijo.28.2.337