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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2006 Volume 28 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2006 Volume 28 Issue 2

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Article

Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo

  • Authors:
    • Martin Michaelis
    • Iduna Fichtner
    • Diana Behrens
    • Wolfram Haider
    • Florian Rothweiler
    • Andreas Mack
    • Jaroslav Cinatl
    • Hans Wilhelm Doerr
    • Jindrich Cinatl

  • View Affiliations / Copyright

    Affiliations: Institut für Medizinische Virologie, Klinikum der Johann Wolfgang Goethe-Universität, D-60596 Frankfurt am Main, Germany
  • Pages: 439-446
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/ijo.28.2.439
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Abstract

The proteasome inhibitor bortezomib (Velcade®) was recently approved for the treatment of therapy-refractive multiple myeloma and is under investigation for numerous other types of cancer. A phase I clinical trial in paediatric patients resulted in tolerable toxicity. Since the emergence of chemoresistance represents one of the major drawbacks in cancer therapy, we investigated the influence of bortezomib on multi-drug resistant human neuroblastoma cell lines characterised by P-glycoprotein expression and p53 mutation. Nanomolar concentrations of bortezomib inhibited the cell cycle and induced apoptosis in chemosensitive as well as in chemoresistant cell lines. in vivo growth of chemosensitive and chemoresistant neuroblastoma cell lines was inhibited to a similar extent. In addition, bortezomib inhibited vessel formation in neuroblastoma xenografts. These findings and the favourable toxicity profile of bortezomib in children make it reasonable to further pursue additional development of the drug for the treatment of neuroblastoma and other paediatric solid tumours.

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Copy and paste a formatted citation
Spandidos Publications style
Michaelis M, Fichtner I, Behrens D, Haider W, Rothweiler F, Mack A, Cinatl J, Doerr HW and Cinatl J: Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo. Int J Oncol 28: 439-446, 2006.
APA
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A. ... Cinatl, J. (2006). Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo. International Journal of Oncology, 28, 439-446. https://doi.org/10.3892/ijo.28.2.439
MLA
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A., Cinatl, J., Doerr, H. W., Cinatl, J."Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo". International Journal of Oncology 28.2 (2006): 439-446.
Chicago
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A., Cinatl, J., Doerr, H. W., Cinatl, J."Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo". International Journal of Oncology 28, no. 2 (2006): 439-446. https://doi.org/10.3892/ijo.28.2.439
Copy and paste a formatted citation
x
Spandidos Publications style
Michaelis M, Fichtner I, Behrens D, Haider W, Rothweiler F, Mack A, Cinatl J, Doerr HW and Cinatl J: Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo. Int J Oncol 28: 439-446, 2006.
APA
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A. ... Cinatl, J. (2006). Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo. International Journal of Oncology, 28, 439-446. https://doi.org/10.3892/ijo.28.2.439
MLA
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A., Cinatl, J., Doerr, H. W., Cinatl, J."Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo". International Journal of Oncology 28.2 (2006): 439-446.
Chicago
Michaelis, M., Fichtner, I., Behrens, D., Haider, W., Rothweiler, F., Mack, A., Cinatl, J., Doerr, H. W., Cinatl, J."Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo". International Journal of Oncology 28, no. 2 (2006): 439-446. https://doi.org/10.3892/ijo.28.2.439
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