Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma

  • Authors:
    • Mari Kuboshima
    • Hideaki Shimada
    • Tian-Ling Liu
    • Kazue Nakashima
    • Fumio Nomura
    • Masaki Takiguchi
    • Takaki Hiwasa
    • Takenori Ochiai
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/ijo.28.2.463
  • Pages: 463-468
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Abstract

We have carried out SEREX (serological identifi-cation of antigens by recombinant cDNA expression cloning), and identified SLC2A1 (solute carrier family 2/facilitated glucose transporter, member 1) as an antigen recognized by serum IgG antibodies in patients with esophageal squamous cell carcinoma (SCC). The levels of serum anti-SLC2A1 antibodies (s-SLC2A1-Abs), examined by enzyme-linked immunosorbent assay using bacterially expressed glutathione-S-transferase-SLC2A1 fusion protein, were significantly higher in patients with esophageal SCC than in healthy donors. When using a cut-off level as the mean + 2x standard deviations of healthy donors, a total of 12 (21%) out of 57 SCC patients were revealed as positive for s-SLC2A1-Abs. The presence of s-SLC2A1-Abs was not associated with either clinicopathological factors or survival. Because s-SLC2A1-Abs were not associated with the positivity of other conventional serum markers, a combination assay of s-SLC2A1-Abs with these conventional serum markers may be useful for the diagnosis and monitoring of esophageal SCC.

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February 2006
Volume 28 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kuboshima M, Shimada H, Liu T, Nakashima K, Nomura F, Takiguchi M, Hiwasa T and Ochiai T: Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. Int J Oncol 28: 463-468, 2006
APA
Kuboshima, M., Shimada, H., Liu, T., Nakashima, K., Nomura, F., Takiguchi, M. ... Ochiai, T. (2006). Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. International Journal of Oncology, 28, 463-468. https://doi.org/10.3892/ijo.28.2.463
MLA
Kuboshima, M., Shimada, H., Liu, T., Nakashima, K., Nomura, F., Takiguchi, M., Hiwasa, T., Ochiai, T."Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma". International Journal of Oncology 28.2 (2006): 463-468.
Chicago
Kuboshima, M., Shimada, H., Liu, T., Nakashima, K., Nomura, F., Takiguchi, M., Hiwasa, T., Ochiai, T."Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma". International Journal of Oncology 28, no. 2 (2006): 463-468. https://doi.org/10.3892/ijo.28.2.463