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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2006 Volume 28 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2006 Volume 28 Issue 6

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Article

Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression

  • Authors:
    • Noriyuki Miyazaki
    • Yoshiyuki Abe
    • Yasuhisa Oida
    • Hiroshi Suemizu
    • Masatake Nishi
    • Hitoshi Yamazaki
    • Masayuki Iwasaki
    • Hiroshi Inoue
    • Yoshito Ueyama
    • Masato Nakamura

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
  • Pages: 1369-1374
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/ijo.28.6.1369
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Abstract

A loss or reduced expression of E-cadherin, the main cell-to-cell adhesion molecule, correlates with distant metastasis in various cancers. Recent studies have reported a close correlation between the expression of E-cadherin and that of S100A4, calcium-binding protein. In this study, we investigated the expression of E-cadherin and S100A4 status in relation to the clinicopathological parameters of pulmonary adenocarcinoma. We finely and quantitatively examined the expression of E-cadherin and S100A4 using real-time polymerase chain reaction (PCR) in a total of 92 pulmonary adenocarcinomas obtained by surgical resection. All of the pulmonary adenocarcinomas showed significant expression of E-cadherin and S100A4. Real-time PCR showed lower E-cadherin expression in 21 adenocarcinomas, while 71 adenocarcinomas expressed a higher expression of E-cadherin. Of 21 adenocarcinomas with lower-expressing E-cadherin, 12 showed a higher expression of S100A4. These 12 cases significantly showed a poorer prognosis than others (p=0.047, Kaplan-Meier, log-rank test) and significantly showed more frequent venous involvement than others (p=0.042, χ2 test). These results suggested that reduced E-cadherin expression combined with higher S100A4 expression is related to a poor prognosis through hematogenous metastasis in pulmonary adenocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Miyazaki N, Abe Y, Oida Y, Suemizu H, Nishi M, Yamazaki H, Iwasaki M, Inoue H, Ueyama Y, Nakamura M, Nakamura M, et al: Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression. Int J Oncol 28: 1369-1374, 2006.
APA
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H. ... Nakamura, M. (2006). Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression. International Journal of Oncology, 28, 1369-1374. https://doi.org/10.3892/ijo.28.6.1369
MLA
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H., Iwasaki, M., Inoue, H., Ueyama, Y., Nakamura, M."Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression". International Journal of Oncology 28.6 (2006): 1369-1374.
Chicago
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H., Iwasaki, M., Inoue, H., Ueyama, Y., Nakamura, M."Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression". International Journal of Oncology 28, no. 6 (2006): 1369-1374. https://doi.org/10.3892/ijo.28.6.1369
Copy and paste a formatted citation
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Spandidos Publications style
Miyazaki N, Abe Y, Oida Y, Suemizu H, Nishi M, Yamazaki H, Iwasaki M, Inoue H, Ueyama Y, Nakamura M, Nakamura M, et al: Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression. Int J Oncol 28: 1369-1374, 2006.
APA
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H. ... Nakamura, M. (2006). Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression. International Journal of Oncology, 28, 1369-1374. https://doi.org/10.3892/ijo.28.6.1369
MLA
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H., Iwasaki, M., Inoue, H., Ueyama, Y., Nakamura, M."Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression". International Journal of Oncology 28.6 (2006): 1369-1374.
Chicago
Miyazaki, N., Abe, Y., Oida, Y., Suemizu, H., Nishi, M., Yamazaki, H., Iwasaki, M., Inoue, H., Ueyama, Y., Nakamura, M."Poor outcome of patients with pulmonary adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression". International Journal of Oncology 28, no. 6 (2006): 1369-1374. https://doi.org/10.3892/ijo.28.6.1369
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