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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2006 Volume 28 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2006 Volume 28 Issue 6

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Article

Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction

  • Authors:
    • Hak-Ryul Kim
    • Eun-Jung Kim
    • Sei-Hoon Yang
    • Eun-Taik Jeong
    • Channy Park
    • Se-Jin Kim
    • Myung-Ja Youn
    • Hong-Seob So
    • Raekil Park
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Wonkwang University, School of Medicine, Jeonbuk 570-749, South Korea
  • Pages: 1401-1408
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/ijo.28.6.1401
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to enhance the responsiveness of tumor cells toward chemotherapeutic drugs and radiation. However, the precise mechanism of synergistic enhancement in tumoricidal activity is not clearly known. Herein, we demonstrate that the combination treatment of arsenic trioxide (As2O3) and sulindac resulted in a synergistic augmentation of cytotoxicity toward NCI-H157 lung cancer cells, which was revealed as apoptosis accompanied by chromatin fragmentation and an increase in sub-G0/G1 fraction. In addition, combination treatment with As2O3 and sulindac increased the catalytic activity of caspase-3, -8, and -9 along with induction of Fas/FasL expression and cytosolic release of cytochrome c. Pharmacologic scavenging study of reactive oxygen species (ROS) revealed that synergistic augmentation of cytotoxicity was achieved by generation of ROS, which might modulate the expression of Bcl-2 family proteins, the activity of caspase-3, and mitochondrial membrane potential transition.

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Copy and paste a formatted citation
Spandidos Publications style
Kim H, Kim E, Yang S, Jeong E, Park C, Kim S, Youn M, So H and Park R: Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. Int J Oncol 28: 1401-1408, 2006.
APA
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S. ... Park, R. (2006). Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. International Journal of Oncology, 28, 1401-1408. https://doi.org/10.3892/ijo.28.6.1401
MLA
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S., Youn, M., So, H., Park, R."Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction". International Journal of Oncology 28.6 (2006): 1401-1408.
Chicago
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S., Youn, M., So, H., Park, R."Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction". International Journal of Oncology 28, no. 6 (2006): 1401-1408. https://doi.org/10.3892/ijo.28.6.1401
Copy and paste a formatted citation
x
Spandidos Publications style
Kim H, Kim E, Yang S, Jeong E, Park C, Kim S, Youn M, So H and Park R: Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. Int J Oncol 28: 1401-1408, 2006.
APA
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S. ... Park, R. (2006). Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. International Journal of Oncology, 28, 1401-1408. https://doi.org/10.3892/ijo.28.6.1401
MLA
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S., Youn, M., So, H., Park, R."Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction". International Journal of Oncology 28.6 (2006): 1401-1408.
Chicago
Kim, H., Kim, E., Yang, S., Jeong, E., Park, C., Kim, S., Youn, M., So, H., Park, R."Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction". International Journal of Oncology 28, no. 6 (2006): 1401-1408. https://doi.org/10.3892/ijo.28.6.1401
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