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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2006 Volume 28 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2006 Volume 28 Issue 6

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Article

Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells

  • Authors:
    • Arabel Vollmann
    • Hans-Peter Vornlocher
    • Thomas Stempfl
    • Gero Brockhoff
    • Rainer Apfel
    • Ulrich Bogdahn

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University of Regensburg, D-93053 Regensburg, Germany. arabel.vollmann@exfor.uni-regensburg.de
  • Pages: 1531-1542
    |
    Published online on: June 1, 2006
       https://doi.org/10.3892/ijo.28.6.1531
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Abstract

The epidermal growth factor receptor (EGFR, ErbB1) is frequently dysregulated in a variety of solid human tumors, including malignant glioma. EGFR expression has been associated with disease progression, resistance to standard therapies and poor survival. The application of small interfering RNAs (siRNAs) has become an effective and highly specific tool to modulate gene expression, and a wide range of oncogenes have been silenced successfully. Here we show the siRNA-mediated down-regulation of EGFR in two established glioma cell lines with different EGFR expression levels (U373 MG, LN18). The expression of EGFR mRNA and protein was down-regulated by 70-90%. However, siRNA treatment had no inhibitory effect on cell proliferation, migration and activation status of EGFR-coupled signaling cascades. In accordance with these results, gene expression analysis with microarrays revealed only small, albeit specific changes in expression patterns. In conclusion, these data indicate that the specific down-regulation of EGFR might not be sufficient for a single agent therapeutic approach in malignant glioma.

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Copy and paste a formatted citation
Spandidos Publications style
Vollmann A, Vornlocher H, Stempfl T, Brockhoff G, Apfel R and Bogdahn U: Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. Int J Oncol 28: 1531-1542, 2006.
APA
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., & Bogdahn, U. (2006). Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. International Journal of Oncology, 28, 1531-1542. https://doi.org/10.3892/ijo.28.6.1531
MLA
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., Bogdahn, U."Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells". International Journal of Oncology 28.6 (2006): 1531-1542.
Chicago
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., Bogdahn, U."Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells". International Journal of Oncology 28, no. 6 (2006): 1531-1542. https://doi.org/10.3892/ijo.28.6.1531
Copy and paste a formatted citation
x
Spandidos Publications style
Vollmann A, Vornlocher H, Stempfl T, Brockhoff G, Apfel R and Bogdahn U: Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. Int J Oncol 28: 1531-1542, 2006.
APA
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., & Bogdahn, U. (2006). Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells. International Journal of Oncology, 28, 1531-1542. https://doi.org/10.3892/ijo.28.6.1531
MLA
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., Bogdahn, U."Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells". International Journal of Oncology 28.6 (2006): 1531-1542.
Chicago
Vollmann, A., Vornlocher, H., Stempfl, T., Brockhoff, G., Apfel, R., Bogdahn, U."Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells". International Journal of Oncology 28, no. 6 (2006): 1531-1542. https://doi.org/10.3892/ijo.28.6.1531
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