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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2006 Volume 29 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 29 Issue 1

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Article

HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells

  • Authors:
    • Katsuhiro Tofuku
    • Masahiro Yokouchi
    • Takashi Murayama
    • Shusaku Minami
    • Setsuro Komiya

  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan
  • Pages: 175-183
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijo.29.1.175
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Abstract

Several studies have suggested that increased production of hyaluronan (HA) is associated with metastatic behavior in various malignant tumors. To our knowledge, HA molecular weights required for metastasis are still unsolved in osteosarcoma. We examined the size of HA and hyaluronan synthase (HAS) isoforms related to biological functions required for metastasis in the LM8 stably highly metastatic osteosarcoma cell line. We found that HA of molecular weight which HAS3 produces enhanced biological functions related to metastasis such as cell proliferation, invasion, and degradation of extracellular matrix. Moreover, cell proliferation and invasion were inhibited by suppressing the activity of HAS3 expressed in LM8 cells, using hyaluronan synthase suppressor, 4-methylumbelliferone (MU). HA with the molecular weight related to HAS2 was the most adherent to CD44 in LM8 cells, suggesting that HAS2 may play an important role in pericellular coat formation. These results suggest that HAS3-related HA enhances crucial biological activities necessary for metastasis and that HAS2-related HA offers an advantageous environment for osteosarcoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Tofuku K, Yokouchi M, Murayama T, Minami S and Komiya S: HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. Int J Oncol 29: 175-183, 2006.
APA
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., & Komiya, S. (2006). HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. International Journal of Oncology, 29, 175-183. https://doi.org/10.3892/ijo.29.1.175
MLA
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., Komiya, S."HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells". International Journal of Oncology 29.1 (2006): 175-183.
Chicago
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., Komiya, S."HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells". International Journal of Oncology 29, no. 1 (2006): 175-183. https://doi.org/10.3892/ijo.29.1.175
Copy and paste a formatted citation
x
Spandidos Publications style
Tofuku K, Yokouchi M, Murayama T, Minami S and Komiya S: HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. Int J Oncol 29: 175-183, 2006.
APA
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., & Komiya, S. (2006). HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. International Journal of Oncology, 29, 175-183. https://doi.org/10.3892/ijo.29.1.175
MLA
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., Komiya, S."HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells". International Journal of Oncology 29.1 (2006): 175-183.
Chicago
Tofuku, K., Yokouchi, M., Murayama, T., Minami, S., Komiya, S."HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells". International Journal of Oncology 29, no. 1 (2006): 175-183. https://doi.org/10.3892/ijo.29.1.175
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