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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2006 Volume 29 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 29 Issue 1

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Article

LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells

  • Authors:
    • Ken Ohnishi
    • Jun-Ichi Yasumoto
    • Akihisa Takahashi
    • Takeo Ohnishi

  • View Affiliations / Copyright

    Affiliations: Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara 634-8521, Japan
  • Pages: 249-253
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijo.29.1.249
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Abstract

The aim of this study was to ascertain whether LY294002, an inhibitor of PI-3K, enhances heat sensitivity in human cancer cells regardless of their p53 status. Colony formation assays showed that LY294002 enhanced heat sensitivity in two human lung cancer cell lines; H1299/wild-type p53 (wtp53) and H1299/mutated p53 (mp53) cells. These cell lines have identical genetic backgrounds except for their p53 status. LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines. Heat-induced apoptosis was observed more frequently in H1299/wtp53 cells than in H1299/mp53 cells, and was enhanced by LY294002 in both cell lines. In addition, both the heat-induced phosphorylation of Akt and the accumulation of survivin were suppressed by LY294002. These results suggest that LY294002 inhibits anti-apoptosis signaling through hsp27 and hsp72 as well as cell survival signaling through Akt and survivin. LY294002 appears to be an attractive candidate for a p53-independent heat sensitizer in hyperthermic cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Ohnishi K, Yasumoto J, Takahashi A and Ohnishi T: LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. Int J Oncol 29: 249-253, 2006.
APA
Ohnishi, K., Yasumoto, J., Takahashi, A., & Ohnishi, T. (2006). LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. International Journal of Oncology, 29, 249-253. https://doi.org/10.3892/ijo.29.1.249
MLA
Ohnishi, K., Yasumoto, J., Takahashi, A., Ohnishi, T."LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells". International Journal of Oncology 29.1 (2006): 249-253.
Chicago
Ohnishi, K., Yasumoto, J., Takahashi, A., Ohnishi, T."LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells". International Journal of Oncology 29, no. 1 (2006): 249-253. https://doi.org/10.3892/ijo.29.1.249
Copy and paste a formatted citation
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Spandidos Publications style
Ohnishi K, Yasumoto J, Takahashi A and Ohnishi T: LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. Int J Oncol 29: 249-253, 2006.
APA
Ohnishi, K., Yasumoto, J., Takahashi, A., & Ohnishi, T. (2006). LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells. International Journal of Oncology, 29, 249-253. https://doi.org/10.3892/ijo.29.1.249
MLA
Ohnishi, K., Yasumoto, J., Takahashi, A., Ohnishi, T."LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells". International Journal of Oncology 29.1 (2006): 249-253.
Chicago
Ohnishi, K., Yasumoto, J., Takahashi, A., Ohnishi, T."LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells". International Journal of Oncology 29, no. 1 (2006): 249-253. https://doi.org/10.3892/ijo.29.1.249
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