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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2006 Volume 29 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 29 Issue 6

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Article

Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours

  • Authors:
    • Jana Símová
    • Jan Bubeník
    • Jana Bieblová
    • Rodney Alexander Rosalia
    • Jan Fric
    • Milan Reinis

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Genetics Academy of Sciences of the Czech Republic, CZ-166 37 Prague 6, Czech Republic
  • Pages: 1567-1571
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijo.29.6.1567
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Abstract

It is generally accepted that T regulatory cells (Treg CD4+CD25+Foxp3+) play an important role in the suppression of tumour immunity. We examined the impact of Treg cell depletion with anti-CD25 antibody as adjuvant therapy in the treatment of minimal residual disease after excision of murine HPV16-associated tumours. We found that the depletion of Treg cells inhibited growth of the recurrences after surgery of HPV16-associated MHC class I+ as well as MHC class I-deficient tumours transplanted in syngeneic mice. These results demonstrate that depletion of CD25+CD4+ Treg cells can be used as an efficient adjuvant treatment improving the results of surgery in the experimental systems mimicking human MHC class I+ and MHC class I-deficient, HPV16-associated neoplasms. Therefore, this therapeutic modality is worth being examined in patients with minimal residual HPV16-associated tumour disease after surgery.

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Copy and paste a formatted citation
Spandidos Publications style
Símová J, Bubeník J, Bieblová J, Rosalia RA, Fric J and Reinis M: Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours. Int J Oncol 29: 1567-1571, 2006.
APA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R.A., Fric, J., & Reinis, M. (2006). Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours. International Journal of Oncology, 29, 1567-1571. https://doi.org/10.3892/ijo.29.6.1567
MLA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29.6 (2006): 1567-1571.
Chicago
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29, no. 6 (2006): 1567-1571. https://doi.org/10.3892/ijo.29.6.1567
Copy and paste a formatted citation
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Spandidos Publications style
Símová J, Bubeník J, Bieblová J, Rosalia RA, Fric J and Reinis M: Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours. Int J Oncol 29: 1567-1571, 2006.
APA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R.A., Fric, J., & Reinis, M. (2006). Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours. International Journal of Oncology, 29, 1567-1571. https://doi.org/10.3892/ijo.29.6.1567
MLA
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29.6 (2006): 1567-1571.
Chicago
Símová, J., Bubeník, J., Bieblová, J., Rosalia, R. A., Fric, J., Reinis, M."Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours". International Journal of Oncology 29, no. 6 (2006): 1567-1571. https://doi.org/10.3892/ijo.29.6.1567
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