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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2007 Volume 30 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January 2007 Volume 30 Issue 1

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Article

Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice

  • Authors:
    • Masayoshi Fukushima
    • Yoshiyuki Hattori
    • Takashi Yoshizawa
    • Yoshie Maitani

  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan
  • Pages: 225-231
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/ijo.30.1.225
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Abstract

Docetaxel (DTX) is used for the treatment of advanced hormone refractory prostate cancer. Connexin 43 (Cx43) is a tumor suppressor gene, and transfection of the Cx43 gene increases sensitivity to several chemotherapeutic agents. The objective of this study was to evaluate the effectiveness of combination therapy of Cx43-expressing plasmid DNA (pCMV-Cx43) and DTX both in vitro and in vivo using a non-viral vector in human prostate cancer PC-3 cells. Transfection of pCMV-Cx43 into the cells neither inhibited tumor growth nor increased gap junctional intercellular communication; however, combination therapy of pCMV-Cx43 and DTX significantly inhibited cell growth. Forced expression of Cx43 in the cells induced apoptotic cells by down-regulation of Bcl-2 expression and significantly more up-regulation of caspase-3 activity than either treatment alone. The combination of repeated intratumoral injection of pCMV-Cx43 (10 µg/tumor) with non-viral vector and a single intravenous injection of DTX (15 mg/kg) was compared with a repeated injection of Cx43 alone and a single injection of DTX alone on PC-3 tumor xenografts. Significant antitumoral effects were observed in mice receiving combined treatment, compared with DTX alone. The data presented here provide a rational strategy for treating patients with advanced hormone refractory prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Fukushima M, Hattori Y, Yoshizawa T and Maitani Y: Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. Int J Oncol 30: 225-231, 2007.
APA
Fukushima, M., Hattori, Y., Yoshizawa, T., & Maitani, Y. (2007). Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. International Journal of Oncology, 30, 225-231. https://doi.org/10.3892/ijo.30.1.225
MLA
Fukushima, M., Hattori, Y., Yoshizawa, T., Maitani, Y."Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice". International Journal of Oncology 30.1 (2007): 225-231.
Chicago
Fukushima, M., Hattori, Y., Yoshizawa, T., Maitani, Y."Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice". International Journal of Oncology 30, no. 1 (2007): 225-231. https://doi.org/10.3892/ijo.30.1.225
Copy and paste a formatted citation
x
Spandidos Publications style
Fukushima M, Hattori Y, Yoshizawa T and Maitani Y: Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. Int J Oncol 30: 225-231, 2007.
APA
Fukushima, M., Hattori, Y., Yoshizawa, T., & Maitani, Y. (2007). Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. International Journal of Oncology, 30, 225-231. https://doi.org/10.3892/ijo.30.1.225
MLA
Fukushima, M., Hattori, Y., Yoshizawa, T., Maitani, Y."Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice". International Journal of Oncology 30.1 (2007): 225-231.
Chicago
Fukushima, M., Hattori, Y., Yoshizawa, T., Maitani, Y."Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice". International Journal of Oncology 30, no. 1 (2007): 225-231. https://doi.org/10.3892/ijo.30.1.225
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