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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2007 Volume 30 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2007 Volume 30 Issue 1

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Article

In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats

  • Authors:
    • Stéphanie Giraud
    • Barbara Bessette
    • Caroline Boda
    • Fabrice Lalloué
    • Daniel Petit
    • Muriel Mathonnet
    • Marie-Odile Jauberteau

  • View Affiliations / Copyright

    Affiliations: Laboratory of Immunology, EA 3842, Homéostasie Cellulaire et Pathologies, University Hospital, 87042 Limoges, France
  • Pages: 273-281
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/ijo.30.1.273
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Abstract

Human glioblastomas that express Fas/CD95 receptor are highly resistant to conventional brain tumour therapies. The aim of this study is to evaluate anti-tumour properties of a combination of Fas ligand (FasL) plus etoposide with or without dexamethasone on intracerebral experimental glioblastomas. The human Fas-expressing glioblastoma cell line, U-87 MG, was firstly studied in vitro for apoptosis and proliferation assays in the presence of FasL and etoposide, separately or associated, in order to detect a supra-additive effect on FasL or etoposide-induced apoptosis. The tumourigenicity of the U-87 MG cell line and therapeutic effects of FasL-etoposide alone or combined with dexamethasone were next studied on U-87 MG cells xenografted to nude-rat brain and tumour size was hence examined by histological and immunohistochemical stainings. We demonstrated in vitro that the combination of both molecules strongly inhibited the proliferation rate and increased the sensitivity of glioblastoma cells to Fas or etoposide-mediated apoptosis. Moreover, analysis of rat brains was performed 30 days after xenograft of glioblastoma cells. These data show that the combination of FasL and etoposide could reduce significantly the tumour size and that the addition of dexamethasone enhanced the inhibiting effect of FasL and etoposide on tumour growth in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Giraud S, Bessette B, Boda C, Lalloué F, Petit D, Mathonnet M and Jauberteau M: In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. Int J Oncol 30: 273-281, 2007.
APA
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., & Jauberteau, M. (2007). In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. International Journal of Oncology, 30, 273-281. https://doi.org/10.3892/ijo.30.1.273
MLA
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., Jauberteau, M."In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats". International Journal of Oncology 30.1 (2007): 273-281.
Chicago
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., Jauberteau, M."In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats". International Journal of Oncology 30, no. 1 (2007): 273-281. https://doi.org/10.3892/ijo.30.1.273
Copy and paste a formatted citation
x
Spandidos Publications style
Giraud S, Bessette B, Boda C, Lalloué F, Petit D, Mathonnet M and Jauberteau M: In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. Int J Oncol 30: 273-281, 2007.
APA
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., & Jauberteau, M. (2007). In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats. International Journal of Oncology, 30, 273-281. https://doi.org/10.3892/ijo.30.1.273
MLA
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., Jauberteau, M."In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats". International Journal of Oncology 30.1 (2007): 273-281.
Chicago
Giraud, S., Bessette, B., Boda, C., Lalloué, F., Petit, D., Mathonnet, M., Jauberteau, M."In vitro apoptotic induction of human glioblastoma cells by Fas ligand plus etoposide and in vivo antitumour activity of combined drugs in xenografted nude rats". International Journal of Oncology 30, no. 1 (2007): 273-281. https://doi.org/10.3892/ijo.30.1.273
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