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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2007 Volume 30 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types

  • Authors:
    • Ana R. Conde
    • Ana P. Martins
    • Miguel Brito
    • Armandina Manuel
    • Sancia Ramos
    • Joana Malta-Vacas
    • Marcus Renner
    • Annemarie Poustka
    • Jan Mollenhauer
    • Carolino Monteiro

  • View Affiliations / Copyright

    Affiliations: Faculdade de Farmacia da Universidade de Lisboa, 1649-003 Lisboa, Portugal. arconde@ff.ul.pt
  • Pages: 1441-1446
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/ijo.30.6.1441
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Abstract

Well-differentiated gastric carcinomas are considered to represent a distinct entity emerging via specific molecular changes different from those found in other gastric carcinoma types. The gene deleted in malignant brain tumours 1 (DMBT1) at 10q25.3-q26.1 codes for a protein presumably involved in cell differentiation and protection and has been proposed as a candidate tumour suppressor for brain and epithelial cancer. One study reported a loss of DMBT1 expression in 12.5% (5/40) of gastric cancer samples. Here, we examined in more detail DMBT1 protein and mRNA expression in 78 primary gastric tumour samples and corresponding normal gastric mucosa. DMBT1 was expressed in all non-tumour gastric mucosa tissues. Eleven out of 71 (15%) gastric tumours were negative for the DMBT1 protein in immunohistochemical analyses. Lack of DMBT1 expression was significantly more frequently found in well-differentiated gastric tumours (6/18 well-differentiated tumours vs. 5/53 other subtypes; P=0.025). Quantitative RT-PCR revealed a downregulation of the DMBT1 mRNA for 8/21 (38%) cases, while the remaining 13 cases (62%) displayed a substantial upregulation. Our data suggest that a loss of DMBT1 expression may preferentially take place in well-differentiated gastric carcinoma. However, an upregulation of DMBT1 expression is more frequently found across all gastric cancer types.

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Copy and paste a formatted citation
Spandidos Publications style
Conde AR, Martins AP, Brito M, Manuel A, Ramos S, Malta-Vacas J, Renner M, Poustka A, Mollenhauer J, Monteiro C, Monteiro C, et al: DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. Int J Oncol 30: 1441-1446, 2007.
APA
Conde, A.R., Martins, A.P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J. ... Monteiro, C. (2007). DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. International Journal of Oncology, 30, 1441-1446. https://doi.org/10.3892/ijo.30.6.1441
MLA
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30.6 (2007): 1441-1446.
Chicago
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30, no. 6 (2007): 1441-1446. https://doi.org/10.3892/ijo.30.6.1441
Copy and paste a formatted citation
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Spandidos Publications style
Conde AR, Martins AP, Brito M, Manuel A, Ramos S, Malta-Vacas J, Renner M, Poustka A, Mollenhauer J, Monteiro C, Monteiro C, et al: DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. Int J Oncol 30: 1441-1446, 2007.
APA
Conde, A.R., Martins, A.P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J. ... Monteiro, C. (2007). DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. International Journal of Oncology, 30, 1441-1446. https://doi.org/10.3892/ijo.30.6.1441
MLA
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30.6 (2007): 1441-1446.
Chicago
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30, no. 6 (2007): 1441-1446. https://doi.org/10.3892/ijo.30.6.1441
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