DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types

  • Authors:
    • Ana R. Conde
    • Ana P. Martins
    • Miguel Brito
    • Armandina Manuel
    • Sancia Ramos
    • Joana Malta-Vacas
    • Marcus Renner
    • Annemarie Poustka
    • Jan Mollenhauer
    • Carolino Monteiro
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/ijo.30.6.1441
  • Pages: 1441-1446
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Abstract

Well-differentiated gastric carcinomas are considered to represent a distinct entity emerging via specific molecular changes different from those found in other gastric carcinoma types. The gene deleted in malignant brain tumours 1 (DMBT1) at 10q25.3-q26.1 codes for a protein presumably involved in cell differentiation and protection and has been proposed as a candidate tumour suppressor for brain and epithelial cancer. One study reported a loss of DMBT1 expression in 12.5% (5/40) of gastric cancer samples. Here, we examined in more detail DMBT1 protein and mRNA expression in 78 primary gastric tumour samples and corresponding normal gastric mucosa. DMBT1 was expressed in all non-tumour gastric mucosa tissues. Eleven out of 71 (15%) gastric tumours were negative for the DMBT1 protein in immunohistochemical analyses. Lack of DMBT1 expression was significantly more frequently found in well-differentiated gastric tumours (6/18 well-differentiated tumours vs. 5/53 other subtypes; P=0.025). Quantitative RT-PCR revealed a downregulation of the DMBT1 mRNA for 8/21 (38%) cases, while the remaining 13 cases (62%) displayed a substantial upregulation. Our data suggest that a loss of DMBT1 expression may preferentially take place in well-differentiated gastric carcinoma. However, an upregulation of DMBT1 expression is more frequently found across all gastric cancer types.

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June 2007
Volume 30 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Conde AR, Martins AP, Brito M, Manuel A, Ramos S, Malta-Vacas J, Renner M, Poustka A, Mollenhauer J, Monteiro C, Monteiro C, et al: DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. Int J Oncol 30: 1441-1446, 2007
APA
Conde, A.R., Martins, A.P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J. ... Monteiro, C. (2007). DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types. International Journal of Oncology, 30, 1441-1446. https://doi.org/10.3892/ijo.30.6.1441
MLA
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30.6 (2007): 1441-1446.
Chicago
Conde, A. R., Martins, A. P., Brito, M., Manuel, A., Ramos, S., Malta-Vacas, J., Renner, M., Poustka, A., Mollenhauer, J., Monteiro, C."DMBT1 is frequently downregulated in well-differentiated gastric carcinoma but more frequently upregulated across various gastric cancer types". International Journal of Oncology 30, no. 6 (2007): 1441-1446. https://doi.org/10.3892/ijo.30.6.1441