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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2007 Volume 30 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2007 Volume 30 Issue 6

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Article

Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo

  • Authors:
    • Yoshinori Nimura
    • Tetsuya Kawata
    • Katsuhiro Uzawa
    • Junko Okamura
    • Cuihua Liu
    • Masayoshi Saito
    • Hideaki Shimada
    • Naohiko Seki
    • Akira Nakagawara
    • Hisao Ito
    • Takenori Ochiai
    • Hideki Tanzawa

  • View Affiliations / Copyright

    Affiliations: 21st Century Center of Excellence Program, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan
  • Pages: 1477-1484
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/ijo.30.6.1477
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Abstract

Ku80 is an important component of DNA double-strand break repair, and Ku80 deficiency leads to extreme sensitivity to ionizing radiation. We studied whether radiation therapy combined with Ku80 silencing by small interfering RNA enhances radiation sensitivity in vitro and in vivo. Seven human cancer cell lines were transfected with Ku80 siRNA included in hemagglutinating virus of Japan envelope vector. H1299 cells were implanted into male BALB/C nu/nu nude mice treated with Ku80 siRNA and irradiation. The survival rate of cell lines transfected with Ku80 siRNA decreased by 10% to 26% with 2-Gy irradiation compared with untransfected cell lines. The gamma-H2AX phosphorylation-positive rates of Ku80 siRNA combined treatment 0.5 h after irradiation in A549 cells and 6 h in H1299 cells were significantly higher (77.6%, p=0.033 and 76.7%, p=0.026, respectively), compared with the groups not treated with siRNA. H1299 xenograft tumors treated with combined therapy decreased in volume and re-grew slowly compared with radiation alone. Our results indicate that combined therapy consisting of Ku80 siRNA and irradiation contributes to inhibition of tumor growth and may be a novel strategy for cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Nimura Y, Kawata T, Uzawa K, Okamura J, Liu C, Saito M, Shimada H, Seki N, Nakagawara A, Ito H, Ito H, et al: Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo. Int J Oncol 30: 1477-1484, 2007.
APA
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M. ... Tanzawa, H. (2007). Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo. International Journal of Oncology, 30, 1477-1484. https://doi.org/10.3892/ijo.30.6.1477
MLA
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M., Shimada, H., Seki, N., Nakagawara, A., Ito, H., Ochiai, T., Tanzawa, H."Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo". International Journal of Oncology 30.6 (2007): 1477-1484.
Chicago
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M., Shimada, H., Seki, N., Nakagawara, A., Ito, H., Ochiai, T., Tanzawa, H."Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo". International Journal of Oncology 30, no. 6 (2007): 1477-1484. https://doi.org/10.3892/ijo.30.6.1477
Copy and paste a formatted citation
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Spandidos Publications style
Nimura Y, Kawata T, Uzawa K, Okamura J, Liu C, Saito M, Shimada H, Seki N, Nakagawara A, Ito H, Ito H, et al: Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo. Int J Oncol 30: 1477-1484, 2007.
APA
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M. ... Tanzawa, H. (2007). Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo. International Journal of Oncology, 30, 1477-1484. https://doi.org/10.3892/ijo.30.6.1477
MLA
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M., Shimada, H., Seki, N., Nakagawara, A., Ito, H., Ochiai, T., Tanzawa, H."Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo". International Journal of Oncology 30.6 (2007): 1477-1484.
Chicago
Nimura, Y., Kawata, T., Uzawa, K., Okamura, J., Liu, C., Saito, M., Shimada, H., Seki, N., Nakagawara, A., Ito, H., Ochiai, T., Tanzawa, H."Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo". International Journal of Oncology 30, no. 6 (2007): 1477-1484. https://doi.org/10.3892/ijo.30.6.1477
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