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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2008 Volume 32 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2008 Volume 32 Issue 1

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Article

Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan

  • Authors:
    • Akinori Sato
    • Keiichi Ito
    • Takako Asano
    • Makoto Sumitomo
    • Tomohiko Asano
    • Masamichi Hayakawa

  • View Affiliations / Copyright

    Affiliations: Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan. zenpaku@ndmc.ac.jp
  • Pages: 171-176
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/ijo.32.1.171
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Abstract

Survivin is an apoptosis inhibitor found in many tumors but not in most normal differentiated tissues, which makes it an exciting target for cancer therapy. Survivin expression has been shown to be associated with cell proliferation in renal cancer and we previously demonstrated the possibility of treating renal cancer with survivin-specific siRNA and topotecan, which increased the uptake of siRNA by KU19-20 renal cancer cells. We found in the present study that the combination of siRNA and topotecan inhibits survivin expression in Caki-1 renal cancer cells by another mechanism. Caki-1 renal cancer cells expressed higher level of survivin than KU19-20 cells did and survivin-specific siRNA alone suppressed survivin expression only slightly. The combination of topotecan and siRNA suppressed survivin expression completely and inhibited cell proliferation. Topotecan itself did not increase cellular uptake of siRNA but suppressed survivin expression. It also increased transfection efficiency without increasing cellular uptake of siRNA. Although the mechanism of action varies between cell lines, combination therapy using topotecan and siRNA should offer an attractive approach for treatment of advanced renal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sato A, Ito K, Asano T, Sumitomo M, Asano T and Hayakawa M: Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan. Int J Oncol 32: 171-176, 2008.
APA
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., & Hayakawa, M. (2008). Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan. International Journal of Oncology, 32, 171-176. https://doi.org/10.3892/ijo.32.1.171
MLA
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., Hayakawa, M."Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan". International Journal of Oncology 32.1 (2008): 171-176.
Chicago
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., Hayakawa, M."Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan". International Journal of Oncology 32, no. 1 (2008): 171-176. https://doi.org/10.3892/ijo.32.1.171
Copy and paste a formatted citation
x
Spandidos Publications style
Sato A, Ito K, Asano T, Sumitomo M, Asano T and Hayakawa M: Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan. Int J Oncol 32: 171-176, 2008.
APA
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., & Hayakawa, M. (2008). Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan. International Journal of Oncology, 32, 171-176. https://doi.org/10.3892/ijo.32.1.171
MLA
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., Hayakawa, M."Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan". International Journal of Oncology 32.1 (2008): 171-176.
Chicago
Sato, A., Ito, K., Asano, T., Sumitomo, M., Asano, T., Hayakawa, M."Topotecan and small interfering RNA suppress survivin expression synergistically in Caki-1 renal cancer cells: Direct suppression of survivin and enhancement of transfection efficiency by topotecan". International Journal of Oncology 32, no. 1 (2008): 171-176. https://doi.org/10.3892/ijo.32.1.171
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