KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression

  • Authors:
    • Shi-Young Park
    • Eun-Hee Seo
    • Hyun Seok Song
    • Seung-Youn Jung
    • Young-Kyoung Lee
    • Kyu-Yang Yi
    • Sung-Eun Yoo
    • Yung-Jin Kim
  • View Affiliations

  • Published online on: June 1, 2008     https://doi.org/10.3892/ijo.32.6.1311
  • Pages: 1311-1315
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Abstract

Angiogenesis is important in the development and progression of cancer, therefore the therapeutic approach based on anti-angiogenesis may represent a promising therapeutic option. KR-31831 is a novel anti-ischemic agent. Previously, we reported the anti-angiogenic activity of KR-31831. In the present study we investigated the molecular mechanisms underlying anti-angiogenic activity of KR-31831. We show that KR-31831 inhibits vascular endothelial growth factor (VEGF)-induced proliferation and tube formation via release of intracellular Ca2+ and phosphorylation of extra-cellular regulated kinase 1/2 (Erk1/2) in human umbilical vein endothelial cells (HUVECs). Moreover, the expression of VEGF receptor 2 (VEGFR2, known as Flk-1 or KDR) was reduced by the treatment of KR-31831. These results suggest that KR-31831 may have inhibitory effects on tumor angiogenesis through down-regulation of KDR expression.

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June 2008
Volume 32 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Park S, Seo E, Song HS, Jung S, Lee Y, Yi K, Yoo S and Kim Y: KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression. Int J Oncol 32: 1311-1315, 2008.
APA
Park, S., Seo, E., Song, H.S., Jung, S., Lee, Y., Yi, K. ... Kim, Y. (2008). KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression. International Journal of Oncology, 32, 1311-1315. https://doi.org/10.3892/ijo.32.6.1311
MLA
Park, S., Seo, E., Song, H. S., Jung, S., Lee, Y., Yi, K., Yoo, S., Kim, Y."KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression". International Journal of Oncology 32.6 (2008): 1311-1315.
Chicago
Park, S., Seo, E., Song, H. S., Jung, S., Lee, Y., Yi, K., Yoo, S., Kim, Y."KR-31831, benzopyran derivative, inhibits VEGF-induced angiogenesis of HUVECs through suppressing KDR expression". International Journal of Oncology 32, no. 6 (2008): 1311-1315. https://doi.org/10.3892/ijo.32.6.1311