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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1994 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1994 Volume 5 Issue 3

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Article

DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY

  • Authors:
    • M SAWAIRI-ITOH
    • A IMAI
    • T MURASE
    • K NIWA
    • N ITOH
    • H MORI
    • T TAMAYA

  • View Affiliations / Copyright

    Affiliations: GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,GIFU 500,JAPAN.
  • Pages: 583-588
    |
    Published online on: September 1, 1994
       https://doi.org/10.3892/ijo.5.3.583
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Abstract

Mutation and overexpression of the p53 gene frequently occur in uterine endometrial carcinomas and endometrioid carcinomas of the ovary. To define the pathogenetic relationship between endometrial neoplasms we examined p53 mutations and allelic losses in these diseases. Genomic deoxyribonucleic acid (DNA) was extracted from 12 endometrioid carcinomas of the ovary and 41 adenocarcinomas and 8 adenosquamous carcinomas of the uterus. Exons 4 through 8 of the p53 gene were amplified by means of the polymerase chain reaction. Mutations in each exon were detected with single-strand conformation polymorphism analysis and characterized with nucleotide sequencing analysis. Five (42%) and 6 (75%) of 12 endometrioid carcinomas were found to have mutations in exons 5 and 7, which encode for the functional domains of p53 molecules and allelic loss of exon 4, respectively. All these patients with aberrant p53 presented at an advanced clinical disease stage. Eighteen percent of the endometrial carcinomas demonstrated a random mutation in exons 5 through 7, and no association was observed between the mutation and the clinical stage and histological grade. The finding of different patterns of p53 mutations in endometrial carcinoma and endometrioid carcinoma suggest that each may follow a different molecular developmental pathway.

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Copy and paste a formatted citation
Spandidos Publications style
SAWAIRI-ITOH M, IMAI A, MURASE T, NIWA K, ITOH N, MORI H and TAMAYA T: DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY. Int J Oncol 5: 583-588, 1994.
APA
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., & TAMAYA, T. (1994). DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY. International Journal of Oncology, 5, 583-588. https://doi.org/10.3892/ijo.5.3.583
MLA
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., TAMAYA, T."DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY". International Journal of Oncology 5.3 (1994): 583-588.
Chicago
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., TAMAYA, T."DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY". International Journal of Oncology 5, no. 3 (1994): 583-588. https://doi.org/10.3892/ijo.5.3.583
Copy and paste a formatted citation
x
Spandidos Publications style
SAWAIRI-ITOH M, IMAI A, MURASE T, NIWA K, ITOH N, MORI H and TAMAYA T: DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY. Int J Oncol 5: 583-588, 1994.
APA
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., & TAMAYA, T. (1994). DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY. International Journal of Oncology, 5, 583-588. https://doi.org/10.3892/ijo.5.3.583
MLA
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., TAMAYA, T."DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY". International Journal of Oncology 5.3 (1994): 583-588.
Chicago
SAWAIRI-ITOH, M., IMAI, A., MURASE, T., NIWA, K., ITOH, N., MORI, H., TAMAYA, T."DIFFERENT PATTERNS OF P53 GENE-MUTATIONS IN ENDOMETRIAL CARCINOMAS AND ENDOMETRIOID CARCINOMAS OF THE OVARY". International Journal of Oncology 5, no. 3 (1994): 583-588. https://doi.org/10.3892/ijo.5.3.583
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