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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1994 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1994 Volume 5 Issue 3

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SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX)

  • Authors:
    • A ORBO
    • R JAEGER
    • G SAGER

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    Affiliations: UNIV TROMSO,INST MED BIOL,DEPT PHARMACOL,N-9037 TROMSO,NORWAY. UNIV TROMSO HOSP,DEPT GYNECOL ONCOL,N-9038 TROMSO,NORWAY.
  • Pages: 619-625
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    Published online on: September 1, 1994
       https://doi.org/10.3892/ijo.5.3.619
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Abstract

About 50% of the cases with invasive carcinoma of the uterine cervix occurs before menopause. Cyclic changes of sex steroids may therefore interfere with the ratio between extracellular levels of cGMP and cAMP (cGMP(ex)/cAMP(ex)). This ratio has been proposed as a diagnostic marker of malignant diseases. In the present study, we tested the ability of sex steroids to affect cAMP and cGMP levels after 96 h exposure, in an established in vitro model of carcinoma of the uterine cervix (C4-I cells). Serum may modify the effects of sex steroids, and due to this, the present experiments were performed both in a chemically defined medium (CDM) and a serum-supplemented medium (SSM). Testosterone caused a concentration-dependent increase of cGMP(ex)/cAMP(ex) in SSM. Progesterone caused a concentration-dependent inhibition of cell growth in SSM and a decrease in cGMP(ex)/cAMP(ex). Progesterone had noed a concentration-dependent increase in cGMP(ex)/cAMP(ex). No distinct effects on, were seen in the other situations. The present study demonstrates that steroids affect the distribution of cGMP and cAMP to the extracellular compartment, and that serum modifies these effects.

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Copy and paste a formatted citation
Spandidos Publications style
ORBO A, JAEGER R and SAGER G: SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX). Int J Oncol 5: 619-625, 1994.
APA
ORBO, A., JAEGER, R., & SAGER, G. (1994). SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX). International Journal of Oncology, 5, 619-625. https://doi.org/10.3892/ijo.5.3.619
MLA
ORBO, A., JAEGER, R., SAGER, G."SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX)". International Journal of Oncology 5.3 (1994): 619-625.
Chicago
ORBO, A., JAEGER, R., SAGER, G."SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX)". International Journal of Oncology 5, no. 3 (1994): 619-625. https://doi.org/10.3892/ijo.5.3.619
Copy and paste a formatted citation
x
Spandidos Publications style
ORBO A, JAEGER R and SAGER G: SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX). Int J Oncol 5: 619-625, 1994.
APA
ORBO, A., JAEGER, R., & SAGER, G. (1994). SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX). International Journal of Oncology, 5, 619-625. https://doi.org/10.3892/ijo.5.3.619
MLA
ORBO, A., JAEGER, R., SAGER, G."SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX)". International Journal of Oncology 5.3 (1994): 619-625.
Chicago
ORBO, A., JAEGER, R., SAGER, G."SERUM MODIFIES THE CONCENTRATION-DEPENDENT EFFECTS THAT SEX STEROIDS EXERT ON CGMP AND CAMP LEVELS, AND THE GROWTH OF HUMAN C4-I CELLS (CARCINOMA OF THE UTERINE CERVIX)". International Journal of Oncology 5, no. 3 (1994): 619-625. https://doi.org/10.3892/ijo.5.3.619
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