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THE EFFECT OF LOW-DOSE OKT3 MONOCLONAL-ANTIBODY THERAPY ON K562 CYTOTOXICITY IN HUMAN CANCER-PATIENTS

  • Authors:
    • J HOLLINGWORTH
    • RE CATTERICK
    • T HORSBURGH
    • PS VEITCH
    • PRF BELL

  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.675
  • Pages: 675-681
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Abstract

Low concentrations of monoclonal antibodies (mAb) specific for the CD3 component of the T cell receptor complex (TcR) may be both immunosuppressive or potent activators of T cell function in vitro depending upon the experimental situation. The anti-CD3 mAb OKT3 is imnmunosuppressive at high doses (5 mg/day for 10 to 14 days) in transplant patients. We undertook a preliminary study to investigate the effect of a single intravenous injection of 50 mu g to 0.5 mu g of OKT3 mAb in cancer patients. OKT3 modulated cytotoxicity with minimal clinical toxicity at low doses and may be of use in cancer immunotherapy protocols.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
HOLLINGWORTH J, CATTERICK R, HORSBURGH T, VEITCH P and BELL P: THE EFFECT OF LOW-DOSE OKT3 MONOCLONAL-ANTIBODY THERAPY ON K562 CYTOTOXICITY IN HUMAN CANCER-PATIENTS. Int J Oncol 5: 675-681, 1994
APA
HOLLINGWORTH, J., CATTERICK, R., HORSBURGH, T., VEITCH, P., & BELL, P. (1994). THE EFFECT OF LOW-DOSE OKT3 MONOCLONAL-ANTIBODY THERAPY ON K562 CYTOTOXICITY IN HUMAN CANCER-PATIENTS. International Journal of Oncology, 5, 675-681. https://doi.org/10.3892/ijo.5.3.675
MLA
HOLLINGWORTH, J., CATTERICK, R., HORSBURGH, T., VEITCH, P., BELL, P."THE EFFECT OF LOW-DOSE OKT3 MONOCLONAL-ANTIBODY THERAPY ON K562 CYTOTOXICITY IN HUMAN CANCER-PATIENTS". International Journal of Oncology 5.3 (1994): 675-681.
Chicago
HOLLINGWORTH, J., CATTERICK, R., HORSBURGH, T., VEITCH, P., BELL, P."THE EFFECT OF LOW-DOSE OKT3 MONOCLONAL-ANTIBODY THERAPY ON K562 CYTOTOXICITY IN HUMAN CANCER-PATIENTS". International Journal of Oncology 5, no. 3 (1994): 675-681. https://doi.org/10.3892/ijo.5.3.675