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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2008 Volume 33 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 33 Issue 4

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Article

The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice

  • Authors:
    • Kinya Okamoto
    • Daniel Neureiter
    • Beate Alinger
    • Matthias Meissnitzer
    • Gabriele Sass
    • Volker Schmitz
    • Pietro Di Fazio
    • Till Wissniowski
    • Susanne Gahr
    • Bernd Hohenstein
    • Bernhard Kaufmann
    • Axel Schlösser
    • Ulrike Haus
    • Eckhart G. Hahn
    • Christoph Herold
    • Matthias Ocker
  • View Affiliations / Copyright

    Affiliations: Department of Medicine 1, University Hospital Erlangen, D-91054 Erlangen, Germany
  • Pages: 733-742
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/ijo_00000059
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Abstract

We investigated the effect of AEE788, a novel dual receptor tyrosine kinase inhibitor of the EGF and the VEGF receptor, for treatment of human HCC cell lines and in a subcutaneous xenograft model. Cell viability and apoptosis of HepG2 and Hep3B cells incubated with 0.1-100 µM AEE788 were quantified. In vivo, HepG2 cells were xenografted to NMRI mice and animals were treated orally with 50 mg/kg AEE788 3x/week. Immunohistochemistry and quantitative Western blotting was performed for pathway analysis in vitro and in vivo. AEE788 reduced growth and induced apoptosis of HCC cells by disrupting mitochondrial transmembrane potentials and inhibiting MAPK phosphorylation. In the xenografts, AEE788 lead to a reduced tumor growth by reducing proliferation and vascularisation. Except for a reversible skin reaction and weight loss, no signs of toxicity were observed. AEE788 is a promising new option for the treatment of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Okamoto K, Neureiter D, Alinger B, Meissnitzer M, Sass G, Schmitz V, Di Fazio P, Wissniowski T, Gahr S, Hohenstein B, Hohenstein B, et al: The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice. Int J Oncol 33: 733-742, 2008.
APA
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V. ... Ocker, M. (2008). The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice. International Journal of Oncology, 33, 733-742. https://doi.org/10.3892/ijo_00000059
MLA
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V., Di Fazio, P., Wissniowski, T., Gahr, S., Hohenstein, B., Kaufmann, B., Schlösser, A., Haus, U., Hahn, E. G., Herold, C., Ocker, M."The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice". International Journal of Oncology 33.4 (2008): 733-742.
Chicago
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V., Di Fazio, P., Wissniowski, T., Gahr, S., Hohenstein, B., Kaufmann, B., Schlösser, A., Haus, U., Hahn, E. G., Herold, C., Ocker, M."The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice". International Journal of Oncology 33, no. 4 (2008): 733-742. https://doi.org/10.3892/ijo_00000059
Copy and paste a formatted citation
x
Spandidos Publications style
Okamoto K, Neureiter D, Alinger B, Meissnitzer M, Sass G, Schmitz V, Di Fazio P, Wissniowski T, Gahr S, Hohenstein B, Hohenstein B, et al: The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice. Int J Oncol 33: 733-742, 2008.
APA
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V. ... Ocker, M. (2008). The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice. International Journal of Oncology, 33, 733-742. https://doi.org/10.3892/ijo_00000059
MLA
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V., Di Fazio, P., Wissniowski, T., Gahr, S., Hohenstein, B., Kaufmann, B., Schlösser, A., Haus, U., Hahn, E. G., Herold, C., Ocker, M."The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice". International Journal of Oncology 33.4 (2008): 733-742.
Chicago
Okamoto, K., Neureiter, D., Alinger, B., Meissnitzer, M., Sass, G., Schmitz, V., Di Fazio, P., Wissniowski, T., Gahr, S., Hohenstein, B., Kaufmann, B., Schlösser, A., Haus, U., Hahn, E. G., Herold, C., Ocker, M."The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice". International Journal of Oncology 33, no. 4 (2008): 733-742. https://doi.org/10.3892/ijo_00000059
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