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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2009 Volume 34 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2009 Volume 34 Issue 1

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Article

GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts

  • Authors:
    • Aikaterini Vassilakos
    • Yoon Lee
    • Stéphane Viau
    • Ningping Feng
    • Hongnan Jin
    • Viengthong Chai
    • Ming Wang
    • Tina Avolio
    • Jim Wright
    • Aiping Young

  • View Affiliations / Copyright

    Affiliations: Lorus Therapeutics Inc., Toronto, Ontario M9W 4Z7, Canada
  • Pages: 33-42
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/ijo_00000126
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Abstract

GTI-2040, an antisense oligonucleotide targeting the small subunit of ribonucleotide reductase, acts as an anti-tumor agent in animal models of human cancer. In the present study, the anti-tumor activity of GTI-2040, in combination with interferon α (IFNα) was investigated against human renal cell carcinoma tumors xenografted into mice. The human renal cell carcinoma cell lines, Caki-1 and A498 were sensitive to IFNα both in vitro and when implanted into mice. In combination with GTI-2040 there were cooperative effects at intermediate doses of the two agents and complete tumor regression at higher combination doses. A control oligonucleotide was not effective as a monotherapy and did not improve the efficacy of IFNα. The effect of combination treatment on apoptosis and proliferation of tumor cells, isolated from xenografted tumors, was examined by histochemistry. GTI-2040 increased the percentage of cells undergoing apoptosis with a concomitant decrease in proliferation. IFNα alone had no effect but in combination with GTI-2040 resulted in increased apoptosis and decreased proliferation compared to GTI-2040 alone. Taken together these results expand the potential clinical applications of GTI-2040 to include combination therapy with IFNα.

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Copy and paste a formatted citation
Spandidos Publications style
Vassilakos A, Lee Y, Viau S, Feng N, Jin H, Chai V, Wang M, Avolio T, Wright J, Young A, Young A, et al: GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts. Int J Oncol 34: 33-42, 2009.
APA
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V. ... Young, A. (2009). GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts. International Journal of Oncology, 34, 33-42. https://doi.org/10.3892/ijo_00000126
MLA
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V., Wang, M., Avolio, T., Wright, J., Young, A."GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts". International Journal of Oncology 34.1 (2009): 33-42.
Chicago
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V., Wang, M., Avolio, T., Wright, J., Young, A."GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts". International Journal of Oncology 34, no. 1 (2009): 33-42. https://doi.org/10.3892/ijo_00000126
Copy and paste a formatted citation
x
Spandidos Publications style
Vassilakos A, Lee Y, Viau S, Feng N, Jin H, Chai V, Wang M, Avolio T, Wright J, Young A, Young A, et al: GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts. Int J Oncol 34: 33-42, 2009.
APA
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V. ... Young, A. (2009). GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts. International Journal of Oncology, 34, 33-42. https://doi.org/10.3892/ijo_00000126
MLA
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V., Wang, M., Avolio, T., Wright, J., Young, A."GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts". International Journal of Oncology 34.1 (2009): 33-42.
Chicago
Vassilakos, A., Lee, Y., Viau, S., Feng, N., Jin, H., Chai, V., Wang, M., Avolio, T., Wright, J., Young, A."GTI-2040 displays cooperative anti-tumor activity when combined with interferon α against human renal carcinoma xenografts". International Journal of Oncology 34, no. 1 (2009): 33-42. https://doi.org/10.3892/ijo_00000126
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