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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2009 Volume 34 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2009 Volume 34 Issue 3

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Article

Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers

  • Authors:
    • Rebecca G. Bagley
    • William Weber
    • Cecile Rouleau
    • Min Yao
    • Nakayuki Honma
    • Shiro Kataoka
    • Isao Ishida
    • Bruce L. Roberts
    • Beverly A. Teicher

  • View Affiliations / Copyright

    Affiliations: Genzyme Corporation, Framingham, MA 01701-9322, USA. rebecca.bagley@genzyme.com
  • Pages: 619-627
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/ijo_00000187
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Abstract

Tumor development is a complex and dynamic process that involves malignant, vascular, and stromal cells. Endosialin is a tumor endothelial marker (TEM) present in the microvasculature and stroma of human tumors. Cancer-associated fibroblasts (CAF) have been implicated in promoting tumor development and have been associated with mesenchymal stem cells (MSC). Since stem/progenitor cells recruited either from bone marrow or residing in nearby tissues can contribute to pathological processes we investigated endosialin in MSC using a novel monoclonal antibody. Endosialin is highly expressed by CAF and human bone marrow-derived MSC. MSC can form networks in a tube formation assay that is inhibited by an anti-endosialin antibody. Immunohistochemistry for human endosialin in xenograft tumors following co-injection of MSC and cancer cells identified MSC in tumor stroma. MSC are a potential target for anticancer therapeutic intervention and endosialin expression offers a new tool for the identification of MSC. Endosialin expression by both CAF and MSC further implies the potential contribution of MSC to tumor stroma via differentiation into tumor stromal fibroblasts.

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Copy and paste a formatted citation
Spandidos Publications style
Bagley RG, Weber W, Rouleau C, Yao M, Honma N, Kataoka S, Ishida I, Roberts BL and Teicher BA: Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. Int J Oncol 34: 619-627, 2009.
APA
Bagley, R.G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S. ... Teicher, B.A. (2009). Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. International Journal of Oncology, 34, 619-627. https://doi.org/10.3892/ijo_00000187
MLA
Bagley, R. G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I., Roberts, B. L., Teicher, B. A."Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers". International Journal of Oncology 34.3 (2009): 619-627.
Chicago
Bagley, R. G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I., Roberts, B. L., Teicher, B. A."Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers". International Journal of Oncology 34, no. 3 (2009): 619-627. https://doi.org/10.3892/ijo_00000187
Copy and paste a formatted citation
x
Spandidos Publications style
Bagley RG, Weber W, Rouleau C, Yao M, Honma N, Kataoka S, Ishida I, Roberts BL and Teicher BA: Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. Int J Oncol 34: 619-627, 2009.
APA
Bagley, R.G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S. ... Teicher, B.A. (2009). Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. International Journal of Oncology, 34, 619-627. https://doi.org/10.3892/ijo_00000187
MLA
Bagley, R. G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I., Roberts, B. L., Teicher, B. A."Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers". International Journal of Oncology 34.3 (2009): 619-627.
Chicago
Bagley, R. G., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I., Roberts, B. L., Teicher, B. A."Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers". International Journal of Oncology 34, no. 3 (2009): 619-627. https://doi.org/10.3892/ijo_00000187
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