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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2009 Volume 34 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2009 Volume 34 Issue 3

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Article

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression

  • Authors:
    • Masami Watanabe
    • Yuji Kashiwakura
    • Peng Huang
    • Kazuhiko Ochiai
    • Junichiro Futami
    • Shun-Ai Li
    • Munenori Takaoka
    • Yasutomo Nasu
    • Masakiyo Sakaguchi
    • Nam-Ho Huh
    • Hiromi Kumon

  • View Affiliations / Copyright

    Affiliations: Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University, Okayama 700-8558, Japan. mwcorrespondence@gmail.com
  • Pages: 657-663
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/ijo_00000191
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Abstract

The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated that recombinant REIC/Dkk-3 protein induced the differentiation of human CD14+ monocytes into a novel cell type (REIC/Dkk-3Mo). REIC/Dkk-3Mo resembles immature dendritic cells generated with IL-4 and GM-CSF. Both these cell populations exhibit similar proportions of CD11c+, CD40+, CD86+ and HLA-DR+ cells and endocytic capacity, but REIC/Dkk-3Mo is negative for CD1a antigen. An analysis of the signal transducers and activators of transcription (STAT) pathways revealed that REIC/Dkk-3 induces phosphorylation of STAT 1 and STAT 3. Furthermore, intratumoral administration of REIC/Dkk-3 protein significantly suppressed tumor growth with CD11c+ and CD8+ (dendritic and killer T cell marker, respectively) cell accumulation and enhanced anti-cancer cytolytic activity of splenocytes. These data indicated a cytokine-like role of REIC/Dkk-3 protein in monocyte differentiation that might be exploited therapeutically.

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Copy and paste a formatted citation
Spandidos Publications style
Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li S, Takaoka M, Nasu Y, Sakaguchi M, Huh N, Huh N, et al: Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression. Int J Oncol 34: 657-663, 2009.
APA
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S. ... Kumon, H. (2009). Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression. International Journal of Oncology, 34, 657-663. https://doi.org/10.3892/ijo_00000191
MLA
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S., Takaoka, M., Nasu, Y., Sakaguchi, M., Huh, N., Kumon, H."Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression". International Journal of Oncology 34.3 (2009): 657-663.
Chicago
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S., Takaoka, M., Nasu, Y., Sakaguchi, M., Huh, N., Kumon, H."Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression". International Journal of Oncology 34, no. 3 (2009): 657-663. https://doi.org/10.3892/ijo_00000191
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li S, Takaoka M, Nasu Y, Sakaguchi M, Huh N, Huh N, et al: Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression. Int J Oncol 34: 657-663, 2009.
APA
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S. ... Kumon, H. (2009). Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression. International Journal of Oncology, 34, 657-663. https://doi.org/10.3892/ijo_00000191
MLA
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S., Takaoka, M., Nasu, Y., Sakaguchi, M., Huh, N., Kumon, H."Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression". International Journal of Oncology 34.3 (2009): 657-663.
Chicago
Watanabe, M., Kashiwakura, Y., Huang, P., Ochiai, K., Futami, J., Li, S., Takaoka, M., Nasu, Y., Sakaguchi, M., Huh, N., Kumon, H."Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression". International Journal of Oncology 34, no. 3 (2009): 657-663. https://doi.org/10.3892/ijo_00000191
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