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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2009 Volume 34 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2009 Volume 34 Issue 3

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Article

Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery

  • Authors:
    • Sun Young Rha
    • Hei Cheul Jeung
    • Min Young Seo
    • Sang Cheol Kim
    • Woo Ick Yang
    • Yong Wha Moon
    • Hyun Cheol Chung

  • View Affiliations / Copyright

    Affiliations: Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120-752, Korea
  • Pages: 837-846
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/ijo_00000210
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Abstract

In breast cancer, changes of gene copy number were analyzed by cDNA microarray-based comparative genome hybridization using post-treatment archived tissues. Genomic DNA was extracted from 45 surgical specimens after chemotherapy. Informative genes were selected by t-test and were statistically validated by prediction analysis using support vector machine in R package. Fluorescence in situ hybridization and quantitative PCR were performed for validation. We developed three clinical models: comparing good vs. poor prognosis (I), comparing good vs. poor prognosis among poor responders (II) and among good responders (III). 158 gene set (I) differentiated high and low risk of relapse group with 92% accuracy. 51 gene set (II) differentiated good and poor prognosis subgroups among poor responders with 99.9% accuracy. 32 gene set (III) differentiated good and poor prognosis subgroups among good responders with 96% accuracy. This approach has potential applications in the identification of high risk of recurrence after neoadjuvant chemotherapy and surgery.

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Copy and paste a formatted citation
Spandidos Publications style
Rha SY, Jeung HC, Seo MY, Kim SC, Yang WI, Moon YW and Chung HC: Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery. Int J Oncol 34: 837-846, 2009.
APA
Rha, S.Y., Jeung, H.C., Seo, M.Y., Kim, S.C., Yang, W.I., Moon, Y.W., & Chung, H.C. (2009). Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery. International Journal of Oncology, 34, 837-846. https://doi.org/10.3892/ijo_00000210
MLA
Rha, S. Y., Jeung, H. C., Seo, M. Y., Kim, S. C., Yang, W. I., Moon, Y. W., Chung, H. C."Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery". International Journal of Oncology 34.3 (2009): 837-846.
Chicago
Rha, S. Y., Jeung, H. C., Seo, M. Y., Kim, S. C., Yang, W. I., Moon, Y. W., Chung, H. C."Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery". International Journal of Oncology 34, no. 3 (2009): 837-846. https://doi.org/10.3892/ijo_00000210
Copy and paste a formatted citation
x
Spandidos Publications style
Rha SY, Jeung HC, Seo MY, Kim SC, Yang WI, Moon YW and Chung HC: Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery. Int J Oncol 34: 837-846, 2009.
APA
Rha, S.Y., Jeung, H.C., Seo, M.Y., Kim, S.C., Yang, W.I., Moon, Y.W., & Chung, H.C. (2009). Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery. International Journal of Oncology, 34, 837-846. https://doi.org/10.3892/ijo_00000210
MLA
Rha, S. Y., Jeung, H. C., Seo, M. Y., Kim, S. C., Yang, W. I., Moon, Y. W., Chung, H. C."Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery". International Journal of Oncology 34.3 (2009): 837-846.
Chicago
Rha, S. Y., Jeung, H. C., Seo, M. Y., Kim, S. C., Yang, W. I., Moon, Y. W., Chung, H. C."Prediction of high-risk patients by genome-wide copy number alterations from remaining cancer after neoadjuvant chemotherapy and surgery". International Journal of Oncology 34, no. 3 (2009): 837-846. https://doi.org/10.3892/ijo_00000210
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