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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2010 Volume 36 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 36 Issue 1

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Article

Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells

  • Authors:
    • Hiroshi Matsudaira
    • Tadashi Asakura
    • Katsuhiko Aoki
    • Yasuyuki Searashi
    • Tomokazu Matsuura
    • Hisato Nakajima
    • Hisao Tajiri
    • Kiyoshi Ohkawa

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine Division of Gastroenterology and Hepatology, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan. hi-matz48@jikei.ac.jp
  • Pages: 77-83
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ijo_00000477
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Abstract

It was confirmed that CD147 (Emmprin) was expressed on the cell surface of carcinoma cells. For the purpose of studying the efficacy of a CD147-targeting agent on CD147-expressing carcinoma cells, we investigated the effect of a conjugate of glutathione-doxorubicin (GSH-DXR) encapsulated in an anti-CD147 antibody-labeled liposome (aCD147ab-liposome) in terms of specific accumulation and cytotoxicity in CD147-expressing human carcinoma cells. Expression of CD147 was not observed in many normal human tissues. However, slight expression of CD147 in kidney, prostate and breast tissues was observed. By contrast, high-level expression of CD147 in all carcinoma cells such as A431, PC3 and Ishikawa cell lines was confirmed by fluorescent microscopy and Western blot analysis. Specific accumulation of the aCD147ab-liposome in the above-described CD147-expressing cells was observed. GSH-DXR encapsulated in an aCD147ab-liposome expressed specific cytotoxicity against these carcinoma cells. These results suggested that target chemotherapy of GSH-DXR encapsulated in an aCD147ab-liposome on CD147-expressing carcinoma cells was effective.

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Copy and paste a formatted citation
Spandidos Publications style
Matsudaira H, Asakura T, Aoki K, Searashi Y, Matsuura T, Nakajima H, Tajiri H and Ohkawa K: Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells. Int J Oncol 36: 77-83, 2010.
APA
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H. ... Ohkawa, K. (2010). Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells. International Journal of Oncology, 36, 77-83. https://doi.org/10.3892/ijo_00000477
MLA
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H., Tajiri, H., Ohkawa, K."Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells". International Journal of Oncology 36.1 (2010): 77-83.
Chicago
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H., Tajiri, H., Ohkawa, K."Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells". International Journal of Oncology 36, no. 1 (2010): 77-83. https://doi.org/10.3892/ijo_00000477
Copy and paste a formatted citation
x
Spandidos Publications style
Matsudaira H, Asakura T, Aoki K, Searashi Y, Matsuura T, Nakajima H, Tajiri H and Ohkawa K: Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells. Int J Oncol 36: 77-83, 2010.
APA
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H. ... Ohkawa, K. (2010). Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells. International Journal of Oncology, 36, 77-83. https://doi.org/10.3892/ijo_00000477
MLA
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H., Tajiri, H., Ohkawa, K."Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells". International Journal of Oncology 36.1 (2010): 77-83.
Chicago
Matsudaira, H., Asakura, T., Aoki, K., Searashi, Y., Matsuura, T., Nakajima, H., Tajiri, H., Ohkawa, K."Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells". International Journal of Oncology 36, no. 1 (2010): 77-83. https://doi.org/10.3892/ijo_00000477
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