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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2010 Volume 36 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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Article

Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects

  • Authors:
    • Seung-Yeol Park
    • Seon-Joo Yoon
    • Sen-Itiroh Hakomori
    • Jin-Man Kim
    • Ji-Yeon Kim
    • Bradford Bernert
    • Thomas Ullman
    • Steven H. Itzkowitz
    • Jung Hoe Kim

  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
  • Pages: 1291-1297
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/ijo_00000614
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Abstract

The glycosyl epitope dimeric Lea (Lea-on-Lea), defined by mouse monoclonal antibody NCC-ST-421, was identified previously as tumor-associated antigen, expressed highly in various human cancer tissues and cell lines derived therefrom, but with minimal expression in various normal tissues. In the present study, we observed clearly higher expression of this epitope, defined by ST421, in β-haptoglobin (β-Hap) from sera of patients with colorectal cancer, compared to normal, healthy subjects or patients with chronic inflammatory processes (Crohn's disease, ulcerative colitis). We focused, therefore, on biochemical characterization of glycosyl epitope status expressed in β-Hap. We concluded that the dimeric Lea epitope is carried by O-linked but not by N-linked structure, based on the following observations: i) Treatment of β-Hap with α-L-fucosidase reduced its reactivity with ST421, but did not affect its reactivity with anti-Hap antibody. In contrast, treatment of purified β-Hap with PNGase F, which releases N-linked glycans, had no effect on reactivity with ST421, but changed molecular mass from 40 kDa to 30 kDa. ii) Strong reactivity of Colo205 supernatant with ST421 was reduced clearly by pre-incubation of cells with benzyl-α-GalNAc.

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Copy and paste a formatted citation
Spandidos Publications style
Park S, Yoon S, Hakomori S, Kim J, Kim J, Bernert B, Ullman T, Itzkowitz SH and Kim JH: Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects. Int J Oncol 36: 1291-1297, 2010.
APA
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B. ... Kim, J.H. (2010). Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects. International Journal of Oncology, 36, 1291-1297. https://doi.org/10.3892/ijo_00000614
MLA
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B., Ullman, T., Itzkowitz, S. H., Kim, J. H."Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects". International Journal of Oncology 36.5 (2010): 1291-1297.
Chicago
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B., Ullman, T., Itzkowitz, S. H., Kim, J. H."Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects". International Journal of Oncology 36, no. 5 (2010): 1291-1297. https://doi.org/10.3892/ijo_00000614
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Yoon S, Hakomori S, Kim J, Kim J, Bernert B, Ullman T, Itzkowitz SH and Kim JH: Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects. Int J Oncol 36: 1291-1297, 2010.
APA
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B. ... Kim, J.H. (2010). Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects. International Journal of Oncology, 36, 1291-1297. https://doi.org/10.3892/ijo_00000614
MLA
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B., Ullman, T., Itzkowitz, S. H., Kim, J. H."Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects". International Journal of Oncology 36.5 (2010): 1291-1297.
Chicago
Park, S., Yoon, S., Hakomori, S., Kim, J., Kim, J., Bernert, B., Ullman, T., Itzkowitz, S. H., Kim, J. H."Dimeric Lea (Lea-on-Lea) status of β-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects". International Journal of Oncology 36, no. 5 (2010): 1291-1297. https://doi.org/10.3892/ijo_00000614
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