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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2010 Volume 37 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 37 Issue 4

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Article

Clarithromycin attenuates autophagy in myeloma cells

  • Authors:
    • Miki Nakamura
    • Yoshitaka Kikukawa
    • Motohiro Takeya
    • Hiroaki Mitsuya
    • Hiroyuki Hata

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Kumamoto University Hospital, Kumamoto 860-8556, Japan
  • Pages: 815-820
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/ijo_00000731
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Abstract

It has been reported that clarithromycin (CAM) augments the anti-tumor activity of thalidomide against multiple myeloma (MM) cells, while the mechanism remains unclear. A myeloma cell line or primary myeloma cells were treated with CAM. Autophagy was analyzed by morphological changes, LC3 expression and lysotracker staining. CAM induced vacuoles in the cytoplasm of MM cells which resembled autolysosomes. The manifestation of the CAM-induced vacuoles was blocked by treatment with PI3-kinase inhibitor. CAM induced an accumulation of LC3-II without affecting the mTOR or AKT pathways, eventually leading to cell death. CAM may halt the autophagy process after fusion of autophagosomes with lysosomes. This phenomenon may explain how CAM, combined with thalidomide, augments the cytotoxic effects of the latter on MM cells and suggests that modification of autophagy might represent a new approach for therapy of MM.

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Copy and paste a formatted citation
Spandidos Publications style
Nakamura M, Kikukawa Y, Takeya M, Mitsuya H and Hata H: Clarithromycin attenuates autophagy in myeloma cells. Int J Oncol 37: 815-820, 2010.
APA
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., & Hata, H. (2010). Clarithromycin attenuates autophagy in myeloma cells. International Journal of Oncology, 37, 815-820. https://doi.org/10.3892/ijo_00000731
MLA
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., Hata, H."Clarithromycin attenuates autophagy in myeloma cells". International Journal of Oncology 37.4 (2010): 815-820.
Chicago
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., Hata, H."Clarithromycin attenuates autophagy in myeloma cells". International Journal of Oncology 37, no. 4 (2010): 815-820. https://doi.org/10.3892/ijo_00000731
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura M, Kikukawa Y, Takeya M, Mitsuya H and Hata H: Clarithromycin attenuates autophagy in myeloma cells. Int J Oncol 37: 815-820, 2010.
APA
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., & Hata, H. (2010). Clarithromycin attenuates autophagy in myeloma cells. International Journal of Oncology, 37, 815-820. https://doi.org/10.3892/ijo_00000731
MLA
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., Hata, H."Clarithromycin attenuates autophagy in myeloma cells". International Journal of Oncology 37.4 (2010): 815-820.
Chicago
Nakamura, M., Kikukawa, Y., Takeya, M., Mitsuya, H., Hata, H."Clarithromycin attenuates autophagy in myeloma cells". International Journal of Oncology 37, no. 4 (2010): 815-820. https://doi.org/10.3892/ijo_00000731
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