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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2010 Volume 37 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 37 Issue 4

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Article

Involvement of C12orf32 overexpression in breast carcinogenesis

  • Authors:
    • Jung-Won Kim
    • Chikako Fukukawa
    • Koji Ueda
    • Toshihiko Nishidate
    • Toyomasa Katagiri
    • Yusuke Nakamura

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
  • Pages: 861-867
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/ijo_00000737
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Abstract

Through genome-wide gene expression profile analysis of breast cancer, we identified a gene, chromosome 12 open reading frame 32 (C12orf32), to be involved in mammary carcinogenesis. Semiquantitative RT-PCR and Northern blot analysis confirmed C12orf32 overexpression in breast cancer cells and its almost undetectable level of expression in normal human tissues. Immunocytochemical staining analysis using breast cancer cell lines revealed a cell cycle-dependent subcellular localization of endogenous C12orf32 protein. Depletion of C12orf32 expression by small-hairpin RNA interference significantly suppressed the growth of breast cancer cell lines possibly due to the inhibition of G1/S transition and subsequent cell death. Western blot analysis indicated that a C12orf32 protein of 35 kDa predicted from the cDNA sequences was processed to a 16-kDa protein of (C12orf32-p16) which was accumulated in most of breast cancer cell lines examined. Our data suggest that C12orf32 is a promising molecular target for the development of novel anticancer drugs such as peptide vaccines and siRNA drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Kim J, Fukukawa C, Ueda K, Nishidate T, Katagiri T and Nakamura Y: Involvement of C12orf32 overexpression in breast carcinogenesis. Int J Oncol 37: 861-867, 2010.
APA
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., & Nakamura, Y. (2010). Involvement of C12orf32 overexpression in breast carcinogenesis. International Journal of Oncology, 37, 861-867. https://doi.org/10.3892/ijo_00000737
MLA
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., Nakamura, Y."Involvement of C12orf32 overexpression in breast carcinogenesis". International Journal of Oncology 37.4 (2010): 861-867.
Chicago
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., Nakamura, Y."Involvement of C12orf32 overexpression in breast carcinogenesis". International Journal of Oncology 37, no. 4 (2010): 861-867. https://doi.org/10.3892/ijo_00000737
Copy and paste a formatted citation
x
Spandidos Publications style
Kim J, Fukukawa C, Ueda K, Nishidate T, Katagiri T and Nakamura Y: Involvement of C12orf32 overexpression in breast carcinogenesis. Int J Oncol 37: 861-867, 2010.
APA
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., & Nakamura, Y. (2010). Involvement of C12orf32 overexpression in breast carcinogenesis. International Journal of Oncology, 37, 861-867. https://doi.org/10.3892/ijo_00000737
MLA
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., Nakamura, Y."Involvement of C12orf32 overexpression in breast carcinogenesis". International Journal of Oncology 37.4 (2010): 861-867.
Chicago
Kim, J., Fukukawa, C., Ueda, K., Nishidate, T., Katagiri, T., Nakamura, Y."Involvement of C12orf32 overexpression in breast carcinogenesis". International Journal of Oncology 37, no. 4 (2010): 861-867. https://doi.org/10.3892/ijo_00000737
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