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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2011 Volume 38 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2011 Volume 38 Issue 1

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Article

Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma

  • Authors:
    • Nijiro Nohata
    • Toyoyuki Hanazawa
    • Naoko Kikkawa
    • Muradil Mutallip
    • Lisa Fujimura
    • Hirofumi Yoshino
    • Kazumori Kawakami
    • Takeshi Chiyomaru
    • Hideki Enokida
    • Masayuki Nakagawa
    • Yoshitaka Okamoto
    • Naohiko Seki
  • View Affiliations / Copyright

    Affiliations: Department of Functional Genomics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 209-217
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/ijo_00000840
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that can function as oncogenes or tumor suppressors in human cancer. Down-regulation of the miRNA miR-133a in many type of cancers, and a reduction of cell proliferation, migration, and invasion upon over-expression, suggests that miR-133a is a tumor suppressor. In this study, genome-wide gene expression analysis of HNSCC cells that over-express miR-133a showed that caveolin-1 (CAV1), a multifunctional scaffolding protein, is down-regulated, a result that was confirmed by real-time PCR and Western blot analysis. A luciferase reporter assay revealed that miR-133a is directly bound to CAV1 mRNA. Cancer cell migration and invasion were significantly inhibited in HNSCC cells transfected with si-CAV1. Therefore, CAV1 functions as an oncogene in HNSCC. The identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of HNSCC carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Fujimura L, Yoshino H, Kawakami K, Chiyomaru T, Enokida H, Nakagawa M, Nakagawa M, et al: Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int J Oncol 38: 209-217, 2011.
APA
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H. ... Seki, N. (2011). Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. International Journal of Oncology, 38, 209-217. https://doi.org/10.3892/ijo_00000840
MLA
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H., Kawakami, K., Chiyomaru, T., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma". International Journal of Oncology 38.1 (2011): 209-217.
Chicago
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H., Kawakami, K., Chiyomaru, T., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma". International Journal of Oncology 38, no. 1 (2011): 209-217. https://doi.org/10.3892/ijo_00000840
Copy and paste a formatted citation
x
Spandidos Publications style
Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Fujimura L, Yoshino H, Kawakami K, Chiyomaru T, Enokida H, Nakagawa M, Nakagawa M, et al: Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int J Oncol 38: 209-217, 2011.
APA
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H. ... Seki, N. (2011). Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. International Journal of Oncology, 38, 209-217. https://doi.org/10.3892/ijo_00000840
MLA
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H., Kawakami, K., Chiyomaru, T., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma". International Journal of Oncology 38.1 (2011): 209-217.
Chicago
Nohata, N., Hanazawa, T., Kikkawa, N., Mutallip, M., Fujimura, L., Yoshino, H., Kawakami, K., Chiyomaru, T., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma". International Journal of Oncology 38, no. 1 (2011): 209-217. https://doi.org/10.3892/ijo_00000840
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