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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature

  • Authors:
    • Kosuke Ueda
    • Shigetaka Suekane
    • Katsuaki Chikui
    • Makoto Nakiri
    • Fukuko Moriya
    • Tokumasa Hayashi
    • Jiro Miyajima
    • Kei Matsuoka
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
  • Pages: 112-116
    |
    Published online on: August 3, 2012
       https://doi.org/10.3892/mco.2012.5
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Abstract

In general, only ≤5% of patients with renal cell carcinoma (RCC) develop paraneoplastic erythropoietin (EPO) overproduction‑induced polycythemia. However, a number of reports on EPO‑producing RCC are available. The present study aimed to report the first case of a patient demonstrating a therapeutic effect on EPO‑producing advanced RCC, subsequent to targeted pre‑surgical sunitinib therapy, with a review of the literature. The patient involved was a 62-year-old male who presented with a malformation of the left scrotum. Examination revealed a tumor of 73 mm in diameter along with lymph node metastasis. The histological examination indicated a clear cell RCC containing viable cells as well as hemorrhage and necrosis. EPO in cancer cells was confirmed by immunohistochemistry. Subsequently, a case of EPO-producing RCC with polycythemia was diagnosed. The EPO-producing RCC was successfully treated following targeted presurgical therapy with sunitinib.
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Copy and paste a formatted citation
Spandidos Publications style
Ueda K, Suekane S, Chikui K, Nakiri M, Moriya F, Hayashi T, Miyajima J and Matsuoka K: Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature. Mol Clin Oncol 1: 112-116, 2013.
APA
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T. ... Matsuoka, K. (2013). Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature. Molecular and Clinical Oncology, 1, 112-116. https://doi.org/10.3892/mco.2012.5
MLA
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T., Miyajima, J., Matsuoka, K."Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature". Molecular and Clinical Oncology 1.1 (2013): 112-116.
Chicago
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T., Miyajima, J., Matsuoka, K."Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature". Molecular and Clinical Oncology 1, no. 1 (2013): 112-116. https://doi.org/10.3892/mco.2012.5
Copy and paste a formatted citation
x
Spandidos Publications style
Ueda K, Suekane S, Chikui K, Nakiri M, Moriya F, Hayashi T, Miyajima J and Matsuoka K: Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature. Mol Clin Oncol 1: 112-116, 2013.
APA
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T. ... Matsuoka, K. (2013). Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature. Molecular and Clinical Oncology, 1, 112-116. https://doi.org/10.3892/mco.2012.5
MLA
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T., Miyajima, J., Matsuoka, K."Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature". Molecular and Clinical Oncology 1.1 (2013): 112-116.
Chicago
Ueda, K., Suekane, S., Chikui, K., Nakiri, M., Moriya, F., Hayashi, T., Miyajima, J., Matsuoka, K."Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature". Molecular and Clinical Oncology 1, no. 1 (2013): 112-116. https://doi.org/10.3892/mco.2012.5
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