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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report

  • Authors:
    • Tsutomu Namikawa
    • Mai Shiga
    • Kengo Ichikawa
    • Hiroyuki Kitagawa
    • Michiya Kobayashi
    • Kazuhiro Hanazaki
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kochi Medical School, Kochi 783-8505, Japan
  • Pages: 249-252
    |
    Published online on: December 14, 2012
       https://doi.org/10.3892/mco.2012.50
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Abstract

A 65-year-old man was referred to our Hospital for examination of gastric cancer initially diagnosed by medical check-up. Esophagogastroduodenoscopy demonstrated a superficial depressed-type gastric cancer in the antrum, and abdominal computed tomography showed no evidence of distant metastases. A tumor measuring 11 mm in diameter was removed by endoscopic submucosal dissection (ESD). Since histological examinations of ESD specimens showed a well‑differentiated adenocarcinoma invading the submucosal layer with lymphatic invasion, the patient subsequently underwent laparoscopy-assisted distal gastrectomy with regional lymph node dissection, resulting in no residual carcinoma and no lymph node metastasis. The patient developed solitary liver metastasis one year later and was treated with trastuzumab plus capecitabine/cisplatin since results of the immunohistochemical analysis of the resected specimens demonstrated overexpression of the human epidermal growth factor receptor 2 (HER2). The patient was alive 12 months after surgical resection of the liver metastasis and subsequently developed bone metastasis. Controversy remains over the role of HER2 status as a prognostic factor in gastric cancer. However, it has been generally reported that HER2 overexpression correlates with aggressive biological behavior and poor prognosis. HER2 overexpression is a potentially useful predictive factor for tumor recurrence and poor prognosis even in early gastric cancer cases.
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Copy and paste a formatted citation
Spandidos Publications style
Namikawa T, Shiga M, Ichikawa K, Kitagawa H, Kobayashi M and Hanazaki K: Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report. Mol Clin Oncol 1: 249-252, 2013.
APA
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., & Hanazaki, K. (2013). Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report. Molecular and Clinical Oncology, 1, 249-252. https://doi.org/10.3892/mco.2012.50
MLA
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., Hanazaki, K."Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report". Molecular and Clinical Oncology 1.2 (2013): 249-252.
Chicago
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., Hanazaki, K."Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report". Molecular and Clinical Oncology 1, no. 2 (2013): 249-252. https://doi.org/10.3892/mco.2012.50
Copy and paste a formatted citation
x
Spandidos Publications style
Namikawa T, Shiga M, Ichikawa K, Kitagawa H, Kobayashi M and Hanazaki K: Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report. Mol Clin Oncol 1: 249-252, 2013.
APA
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., & Hanazaki, K. (2013). Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report. Molecular and Clinical Oncology, 1, 249-252. https://doi.org/10.3892/mco.2012.50
MLA
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., Hanazaki, K."Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report". Molecular and Clinical Oncology 1.2 (2013): 249-252.
Chicago
Namikawa, T., Shiga, M., Ichikawa, K., Kitagawa, H., Kobayashi, M., Hanazaki, K."Metachronous liver and bone metastasis from small early gastric carcinoma without lymph node involvement: A case report". Molecular and Clinical Oncology 1, no. 2 (2013): 249-252. https://doi.org/10.3892/mco.2012.50
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