Significance of clinical factors as prognostic indicators for patients with peripheral T‑cell non‑Hodgkin lymphoma: A retrospective analysis of 252 cases

Xie,Wanzhuo; Hu,Keyue; Xu,Fan; Zhou,De; Huang,Weijia; He,Jingsong; Shi,Jimin; Luo,Yi; Zhang,Jie; Lin,Maofang; Ye,Xiujin; Cai,Zhen; Huang,He

doi:10.3892/mco.2013.146

September-October 2013 Volume 1 Issue 5

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September-October 2013 Volume 1 Issue 5

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Article

Significance of clinical factors as prognostic indicators for patients with peripheral T‑cell non‑Hodgkin lymphoma: A retrospective analysis of 252 cases

Authors:
- Wanzhuo Xie
- Keyue Hu
- Fan Xu
- De Zhou
- Weijia Huang
- Jingsong He
- Jimin Shi
- Yi Luo
- Jie Zhang
- Maofang Lin
- Xiujin Ye
- Zhen Cai
- He Huang
View Affiliations / Copyright

Affiliations: Department of Hematology, Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Pages: 911-917
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Published online on: July 12, 2013

https://doi.org/10.3892/mco.2013.146
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Abstract

The aim of this study was to retrospectively analyze the significance of different clinical factors for predicting the prognosis of patients with peripheral T‑cell non‑Hodgkin lymphoma (PTCL) with a median follow‑up of 23 months. A total of 252 PTCL patients admitted to the First Affiliated Hospital of the School of Medicine of Zhejiang University between 2005 and 2011 were retrospectively reviewed. At a median follow‑up of 23 months, the overall survival (OS) rate was 23.8%. Our results revealed that the presence of B symptoms (P<0.001), Eastern Cooperative Oncology Group (ECOG) score ≥2 (P<0.001), bone marrow involvement (BMI) (P<0.001), elevated lactate dehydrogenase (LDH) levels (P<0.001), elevated β2‑MG levels (P<0.001), Ann Arbor stages III/IV (P=0.007) and International prognostic index (IPI) ≥3 (P=0.001) were poor prognostic factors for OS and intensive chemotherapy achieved a better OS outcome compared to the CHOP treatment. In conclusion, elevated LDH and β2‑MG levels, B symptoms, Ann Arbor stages III̸IV, BMI, high IPIs and high ECOG scores predict an unfavorable prognosis for PTCL patients. compared to the conventional CHOP regimen, the intensive chemotherapy treatment may improve the prognosis of PTCL patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of clinical factors as prognostic indicators for patients with peripheral T‑cell non‑Hodgkin lymphoma: A retrospective analysis of 252 cases

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