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Article

Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy

  • Authors:
    • Kwan Woo Kim
    • Hyuk‑Chan Kwon
    • Sung‑Hyun Kim
    • Sung Yong Oh
    • Suee Lee
    • Ji Hyun Lee
    • Myung Hwan Roh
    • Min Chan Kim
    • Ki Han Kim
    • Young Hoon Kim
    • Young Hoon Roh
    • Jin Sook Jeong
    • Hyo‑Jin Kim
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, Republic of Korea, Department of Internal Medicine, College of Medicine, Dong‑A University, Busan, Republic of Korea, Department of Surgery, College of Medicine, Dong‑A University, Busan, Republic of Korea, Department of Pathology, College of Medicine, Dong‑A University, Busan, Republic of Korea
  • Pages: 987-994
    |
    Published online on: August 6, 2013
       https://doi.org/10.3892/mco.2013.166
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Abstract

Biliary tract cancer (BTC) is a relatively uncommon type of cancer, accounting for ~4% of the malignant neoplasms of the gastrointestinal tract. The aim of this study was to determine whether the expression of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) predict clinical outcome in BTC patients treated with adjuvant 5‑fluorouracil (5‑FU)‑based chemotherapy. TS and TP expression were found to be significantly correlated with cancer location (P=0.044 and 0.031, respectively). The multivariate analysis revealed that age [hazard ratio (HR)=2.157, P=0.008], stage (HR=2.234, P<0.001), resection margin status (HR=2.748, P=0.004) and TP expression (HR=2.014, P=0.039) were independently associated with overall survival (OS).
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Copy and paste a formatted citation
Spandidos Publications style
Kim KW, Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Roh MH, Kim MC, Kim KH, Kim YH, Kim YH, et al: Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy. Mol Clin Oncol 1: 987-994, 2013.
APA
Kim, K.W., Kwon, H., Kim, S., Oh, S.Y., Lee, S., Lee, J.H. ... Kim, H. (2013). Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy. Molecular and Clinical Oncology, 1, 987-994. https://doi.org/10.3892/mco.2013.166
MLA
Kim, K. W., Kwon, H., Kim, S., Oh, S. Y., Lee, S., Lee, J. H., Roh, M. H., Kim, M. C., Kim, K. H., Kim, Y. H., Roh, Y. H., Jeong, J. S., Kim, H."Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy". Molecular and Clinical Oncology 1.6 (2013): 987-994.
Chicago
Kim, K. W., Kwon, H., Kim, S., Oh, S. Y., Lee, S., Lee, J. H., Roh, M. H., Kim, M. C., Kim, K. H., Kim, Y. H., Roh, Y. H., Jeong, J. S., Kim, H."Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy". Molecular and Clinical Oncology 1, no. 6 (2013): 987-994. https://doi.org/10.3892/mco.2013.166
Copy and paste a formatted citation
x
Spandidos Publications style
Kim KW, Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Roh MH, Kim MC, Kim KH, Kim YH, Kim YH, et al: Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy. Mol Clin Oncol 1: 987-994, 2013.
APA
Kim, K.W., Kwon, H., Kim, S., Oh, S.Y., Lee, S., Lee, J.H. ... Kim, H. (2013). Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy. Molecular and Clinical Oncology, 1, 987-994. https://doi.org/10.3892/mco.2013.166
MLA
Kim, K. W., Kwon, H., Kim, S., Oh, S. Y., Lee, S., Lee, J. H., Roh, M. H., Kim, M. C., Kim, K. H., Kim, Y. H., Roh, Y. H., Jeong, J. S., Kim, H."Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy". Molecular and Clinical Oncology 1.6 (2013): 987-994.
Chicago
Kim, K. W., Kwon, H., Kim, S., Oh, S. Y., Lee, S., Lee, J. H., Roh, M. H., Kim, M. C., Kim, K. H., Kim, Y. H., Roh, Y. H., Jeong, J. S., Kim, H."Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5‑fluorouracil‑based chemotherapy". Molecular and Clinical Oncology 1, no. 6 (2013): 987-994. https://doi.org/10.3892/mco.2013.166
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