The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors

Karabulut,Senem; Keskin,Serkan; Ekenel,Meltem; Basaran,Mert; Agaoglu,Fulya; Ozger,Harzem; Bavbek,Sevil

doi:10.3892/mco.2013.185

November-December 2013 Volume 1 Issue 6

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November-December 2013 Volume 1 Issue 6

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Article

The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors

Authors:
- Senem Karabulut
- Serkan Keskin
- Meltem Ekenel
- Mert Basaran
- Fulya Agaoglu
- Harzem Ozger
- Sevil Bavbek
View Affiliations / Copyright

Affiliations: Department of Medical Oncology, Institute of Oncology, Istanbul University, 34390 Istanbul, Turkey, Department of Radiation Oncology, Institute of Oncology, Istanbul University, 34390 Istanbul, Turkey, Department of Orthopedics and Traumatology, Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey
Pages: 1061-1064
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Published online on: September 17, 2013

https://doi.org/10.3892/mco.2013.185
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Abstract

Desmoid tumors (DTs) are benign tumors that exhibit fibroblastic proliferation, which arises from fascial or musculoaponeurotic structures. The aim of this study was to investigate the characteristics and outcomes of patients with resectable DTs. A total of 21 patients were included and their clinicopathological characteristics were retrospectively analyzed. The 21 patients (16 females and 5 males) were identified through reviewing the patient charts at our institute. The tumor was located in the lower extremities in 7 cases, in the upper extremities in 4 cases, in the abdominal region in 9 cases and in the neck region in 1 case. patients who had been initially treated by surgical excision were included in the study. Of these 21 patients, a positive surgical margin (SM) was reported in 11 patients, 7 of whom received postoperative radiotherapy (RT). Ten patients had a negative SM and 6 received RT. A total of 5 patients (46%) in the positive SM group and 4 (40%) in the negative SM group had documented disease relapse (P>0.05). The median relapse‑free survival (RFS) was 20.5 months for the patients treated by surgery alone and 50 months for those treated with surgery followed by adjuvant RT (P>0.05). Age, gender, SM and adjuvant RT were not identified as predictors of recurrence. No predictive factors appeared to indicate local DT recurrence following surgery.

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1.	Pikaar A, Nortier JW, Griffioen G and Vasen HF: Desmoid tumors in patients with familial adenomatous polyposis. Ned Tijdschr Geneeskd. 146:1355–1359. 2001.(In Dutch).
2.	Reitamo JJ, Hayry P, Nykyri E and Saxen E: The desmoid tumor. I. incidence, sex, age and anatomical distribution in the Finnish population. Am J Clin Pathol. 77:665–673. 1982.PubMed/NCBI
3.	Lewis JJ, Boland PJ, Leung DH, Woodruff JM and Brennan MF: The enigma of desmoid tumors. Ann Surg. 229:866–873. 1999. View Article : Google Scholar : PubMed/NCBI
4.	Wara WM, Phillips TL, Hill DR, et al: Desmoid tumors - treatment and prognosis. Radiology. 124:225–226. 1977. View Article : Google Scholar : PubMed/NCBI
5.	Khorsand J and Karakousis CP: Desmoid tumors and their management. Am J Surg. 149:215–218. 1985. View Article : Google Scholar
6.	Posner MC, Shiu MH, Newsome JL, Hajdu SI, Gaynor JJ and Brennan MF: The desmoid tumor. Not a benign disease. Arch Surg. 124:191–196. 1989. View Article : Google Scholar : PubMed/NCBI
7.	Anthony T, Rodriguez-Bigas MA, Weber TK and Petrelli NJ: Desmoid tumors. J Am Coll Surg. 182:369–377. 1996.
8.	Lynch HT and Fitzgibbons R: Surgery, desmoid tumors, and familial adenomatous polyposis: case report and literature review. Am J Gastroenterol. 91:2598–2601. 1996.PubMed/NCBI
9.	Merchant NB, Lewis JJ, Wodruff JM, Leung DH and Brennan MF: Extremity and trunk desmoid tumors: a multifactorial analysis outcome. Cancer. 86:2045–2052. 1999. View Article : Google Scholar : PubMed/NCBI
10.	Ballo MT, Zagars GK, Pollack A, Pisters PW and Pollack RA: Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol. 17:158–167. 1999.PubMed/NCBI
11.	Meazza C, Bisogno G, Gronchi A, et al: Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer. 116:233–240. 2010.PubMed/NCBI
12.	Nuyttens JJ, Rust PF, Thomas CR and Turrisi AT III: Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles. Cancer. 88:1517–1523. 2000. View Article : Google Scholar : PubMed/NCBI
13.	Lev D, Kotilingam D, Wei C, et al: Optimizing treatment of desmoid tumors. J Clin Oncol. 25:1785–1791. 2007. View Article : Google Scholar : PubMed/NCBI
14.	Reitamo JJ: The desmoid tumor. IV. Choice of treatment, results, and complications. Arch Surg. 118:1318–1322. 1983. View Article : Google Scholar : PubMed/NCBI
15.	Gronchi A, Casali PG, Mariani L, et al: Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol. 21:1390–1397. 2003. View Article : Google Scholar : PubMed/NCBI
16.	Ballo MT, Zagars GK and Pollack A: Radiation therapy in the management of desmoid tumors. Int J Radiat Oncol Biol Phys. 42:1007–1014. 1998. View Article : Google Scholar : PubMed/NCBI
17.	Micke O and Seegenschmiedt MH: Radiation therapy for aggressive fibromatosis (desmoid tumors): results of a national patterns of care study. Int J Radiat Oncol Biol Phys. 61:882–891. 2005. View Article : Google Scholar : PubMed/NCBI
18.	Spear MA, Jennings LC, Mankin HJ, et al: Individualizing management of aggressive fibromatoses. Int J Radiat Oncol Biol Phys. 40:637–645. 1998. View Article : Google Scholar : PubMed/NCBI
19.	Bonvalot S, Eldweny H, Haddad V, et al: Extra-abdominal primary fibromatosis: Aggressive management could be avoided in a subgroup of patients. Eur J Surg Oncol. 34:462–468. 2008. View Article : Google Scholar : PubMed/NCBI
20.	Fiore M, Rimareix F, Mariani L, et al: Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol. 16:2587–2593. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors

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