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Article

Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients

  • Authors:
    • Daisuke Furukawa
    • Tsuyoshi Chijiwa
    • Masahiro Matsuyama
    • Masaya Mukai
    • Ei-ichi Matsuo
    • Osamu Nishimura
    • Kenji Kawai
    • Hiroshi Suemizu
    • Nobuyoshi Hiraoka
    • Toshio Nakagohri
    • Seiei Yasuda
    • Masato Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa259‑1193, Japan, Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210‑0821, Japan, Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259‑1193, Japan, Global Application Development Center, Analytical and Measuring Instruments Division, Shimadzu Corporation, Kyoto 604‑8511, Japan, The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650‑0017, Japan, Pathological Analysis Center, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210‑0821, Japan, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104‑0045, Japan, Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259‑1193, Japan
  • Pages: 709-713
    |
    Published online on: May 29, 2014
       https://doi.org/10.3892/mco.2014.298
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Abstract

LIM domain proteins are involved in several fundamental biological processes, including cell lineage specification, cytoskeleton organization and organ development. Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P<0.0001 and P=0.036, respectively). Therefore, ZNF185 expression was found to be an independent indicator of liver metastasis and prognosis in patients with colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Furukawa D, Chijiwa T, Matsuyama M, Mukai M, Matsuo E, Nishimura O, Kawai K, Suemizu H, Hiraoka N, Nakagohri T, Nakagohri T, et al: Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients. Mol Clin Oncol 2: 709-713, 2014.
APA
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O. ... Nakamura, M. (2014). Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients. Molecular and Clinical Oncology, 2, 709-713. https://doi.org/10.3892/mco.2014.298
MLA
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O., Kawai, K., Suemizu, H., Hiraoka, N., Nakagohri, T., Yasuda, S., Nakamura, M."Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients". Molecular and Clinical Oncology 2.5 (2014): 709-713.
Chicago
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O., Kawai, K., Suemizu, H., Hiraoka, N., Nakagohri, T., Yasuda, S., Nakamura, M."Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients". Molecular and Clinical Oncology 2, no. 5 (2014): 709-713. https://doi.org/10.3892/mco.2014.298
Copy and paste a formatted citation
x
Spandidos Publications style
Furukawa D, Chijiwa T, Matsuyama M, Mukai M, Matsuo E, Nishimura O, Kawai K, Suemizu H, Hiraoka N, Nakagohri T, Nakagohri T, et al: Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients. Mol Clin Oncol 2: 709-713, 2014.
APA
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O. ... Nakamura, M. (2014). Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients. Molecular and Clinical Oncology, 2, 709-713. https://doi.org/10.3892/mco.2014.298
MLA
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O., Kawai, K., Suemizu, H., Hiraoka, N., Nakagohri, T., Yasuda, S., Nakamura, M."Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients". Molecular and Clinical Oncology 2.5 (2014): 709-713.
Chicago
Furukawa, D., Chijiwa, T., Matsuyama, M., Mukai, M., Matsuo, E., Nishimura, O., Kawai, K., Suemizu, H., Hiraoka, N., Nakagohri, T., Yasuda, S., Nakamura, M."Zinc finger protein 185 is a liver metastasis‑associated factor in colon cancer patients". Molecular and Clinical Oncology 2, no. 5 (2014): 709-713. https://doi.org/10.3892/mco.2014.298
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